研究業績

1. Kita M, Nakae J, Kawano Y, Asahara H, Takemori H, Okado H, Itoh H. (2019) Zfp238 regulates the thermogenic program in cooperation with Foxo1. iScience. 12:87-101.
2. Yamasaki S, Ando S, Richards M, Hatch SL, Koike S, Fujikawa S, Kanata S, Endo K, Morimoto Y, Arai M, Okado H, Usami S, Furukawa TA, Hiraiwa-Hasegawa M, Kasai K, Nishida A. Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring: A population-based birth cohort study. Schizophr Res. (2019) 206:52-57
3. Okado H. (2019) Regulation of brain development and brain function by the transcriptional repressor RP58. Brain Res. 1705:15-23.
4. Endo K, Ishigaki S, Masamizu Y, Fujioka Y, Watakabe A, Yamamori T, Hatanaka N, Nambu A, Okado H, Katsuno M, Watanabe H, Matsuzaki M, Sobue G. (2018) Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA. Neurosci Res. 130:56-64
5. Parekh PK, Becker-Krail D, Sundaravelu P, Ishigaki S, Okado H, Sobue G, Huang Y, McClung CA. Altered GluA1 (Gria1) (2018) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania. Biol Psychiatry. 84:817–826.
6. Hirai S, Hotta K, Okado (2018) Developmental roles and evolutionary significance of AMPA-type glutamate receptors BioEssays, 40:e1800028.
7. Ken-ichi Inoue K, Miyachi S, Nishi K, Okado H, Nagai Y, Minamimoto T, Nambu A, Takada M.
   Recruitment of calbindin into nigral dopamine neurons protects against drug-induced parkinsonism. Movement Disorders 34(2):200-209.
8. Toda H, Kawasaki K, Sato S, Horie M, Nakahara K, Bepari AK, Sawahata H, Suzuki T, Okado H, Takebayashi H, Hasegawa I.
   Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion. Sci Rep. 2018 May 16;8(1):7678. doi: 10.1038/s41598-018-
9. Nonaka T, Masuda-Suzukake M, Hosokawa M, Shimozawa A, Hirai S, Okado H, Hasegawa M.
   C9ORF72 dipeptide repeat poly-GA inclusions promote: intracellular aggregation of phosphorylated TDP-43. Hum Mol Genet. 2018, Vol. 27, No. 15 2658–2670
10. Ohtaka-Maruyama C, Okamoto M, Endo K, Oshima M, Kaneko N, Yura K, Okado H, Miyata T, Maeda N.
    Synaptic transmission from subplate neurons controls radial migration of neocortical neurons. Science. 2018 360(6386):313-317
11. Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G
    3’UTR length-dependent control of SynGAP isoform α2 mRNA by FUS and ELAV-like proteins promotes dendritic spine maturation and cognitive function Cell Rep 2017, 20:3071-3084
12. Hirai S, Hotta K, Kubo Y, Nishino A, Okabe S, Okamura Y, *Okado H. (2017) AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate Proc Natl Acad Sci USA. 114:3939-3944.
13. Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno M, *Sobue G. (2017) Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes. Cell Rep. 18:1118-1131.
14. Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M. (2016)
    Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43. J Biol Chem. 2016 Mar 11;291(11):5473-83.
15. Ohtaka-Maruyama C, Okado H. (2015) Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development. Front Neurosci. 2015 Dec 17;9:447.
16. Nakajima K, Hirai S, Morio T, Okado H (2015) Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus. Epilepsy & Behavior 52:180-6.
17. Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S, Sobue G.(2015)
    Fus regulates AMPA receptor function and FTLD/ALS-associatted behavior via GluA1 mRNA stabilization. Nat Commun. 2015 May 13 doi:10.1038/ncomms8098
18. Heng JI, Qu Z, Ohtaka-Maruyama C, Okado H, Kasai M, Castro D, Guillemot F, Tan SS.(2015)
    The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development.
    Cereb Cortex. 2015 Mar;25(3):806-16.
19. Yamashita M, Nonaka T, Hirai S, Miwa A, Okado H, Arai T, Hosokawa M, Akiyama H, Hasegawa M.
    Distinct pathways leading to TDP-43-induced cellular dysfunctions.
    Hum Mol Genet. 2014 Aug 15;23(16):4345-56.
20. Hayashizaki S, Hirai S, Ito Y, Honda Y, Arime Y, Sora I, Okado H, Kodama T, Takada M.
    Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.
    PLoS One. 2013 Oct 14;8(10):e75975.
21. Ohtaka-Maruyama C, Hirai S, Miwa A, Heng JI, Shitara H, Ishii R, Taya C, Kawano H, Kasai M, Nakajima K, Okado H. (2013) RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex. Cell Rep. 3:458-71.
22. Hirai S, Miwa A, Ohtaka-Maruyama C, Kasai M, Okabe S, Hata Y, Okado H. (2012) RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex. EMBO J 31:1190-202.
23. Ohtaka-Maruyama C, Hirai S, Miwa A, Takahashi A, Okado H (2012) The 5'-flanking region of the RP58 coding sequence shows prominent promoter activity in multipolar cells in the subventricular zone during corticogenesis. Neuroscience. 201:67-84
24. Mizutani R, Nakamura K, Yokoyama S, Sanbe A, Kusakawa S, Miyamoto Y, Torii T, Asahara H, Okado H, Yamauchi J, Tanoue A (2011) Developmental expression of sorting nexin 3 in the mouse central nervous system. Gene Expr Patterns 11:33-40
25. Takahashi N, Hatakeyama H, Okado H, Noguchi J, Ohno M, Kasai H (2010) SNARE conformational changes that prepare vesicles for exocytosis. Cell Metab 12, 19-29.
26. Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe, K, Mitsuoka, K. Miyaki, S, Kiso M, Nagai A, Fukuda N, Puri L, Kasai M, Hayashizaki Y, Okado H, Hashimoto, M, Asahara H (2009) A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell 17, 836-48
27. Okado H, Ohtaka-Maruyama C, Sugitani Y, Fukuda Y, Ishida R, Hirai S, Miwa A, Takahashi A, Aoki K, Mochida K, Suzuki O, Honda T, Nakajima K, Ogawa M, Terashima T, Matsuda J, Kawano H, Kasai M. (2009) The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev Biol 331, 140-151
28. Takahashi A, Hirai S, Ohtaka-Maruyama C, Miwa A, Hata Y, Okabe S, Okado H. Co-localization of a novel transcriptional repressor simiRP58 with RP58. Biochem Biophys Res Commun. 2008 Apr 11;368(3):637-42
29. Ishiuchi S, Yoshida Y, Sugawara K, Aihara M, Ohtani T, Watanabe T, Saito N, Tsuzuki K, Okado H, Miwa A, Nakazato Y, Ozawa S. Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. J Neurosci. 2007 Jul 25;27(30):7987-8001.
30. Tanaka Y, Okado H, Terashima T. Retrograde infection of precerebellar nuclei neurons by injection of a recombinant adenovirus into the cerebellar cortex of normal and reeler mice.　Arch Histol Cytol. 2007 Apr;70(1):51-62.
31. Nakai M, Fujita M, Waragai M, Sugama S, Wei J, Akatsu H, Ohtaka-Maruyama C, Okado H, Hashimoto M. Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage. Biochem Biophys Res Commun. 2007 Jun 22;358(1):104-10.
32. Ohtaka-Maruyama C, Miwa A, Kawano H, Kasai M, Okado H. Spatial and temporal expression of RP58, a novel zinc finger transcriptional repressor, in mouse brain. J Comp Neurol. 2007 Jun 20;502(6):1098-108.
33. Shimizu H, Watanabe E, Hiyama TY, Nagakura A, Fujikawa A, Okado H, Yanagawa Y, Obata K, Noda M. Glial Nax channels control lactate signaling to neurons for brain [Na+] sensing. Neuron. 2007 Apr 5;54(1):59-72.

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