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Mechanisms of Neural Network Development and Their Disorders

Project Leader Nobuaki Maeda

Leader Nobuaki Maeda

Backgrounds

Neurons that are newly born in the developing brain migrate to their final destinations, and then extend neurites and form synapses on their specific targets. Incidence of abnormalities in these processes of neural circuit formation is believed to be the cause of various neurological disorders, including cortical dysplasia.

This project seeks to develop new methods of treatment of psychiatric and neurological disorders by elucidating molecular mechanism of neural circuit formation mainly focusing on the neuronal migration and synapse formation.

Objectives

  • To elucidate the molecular mechanism of neural circuit formation regulated by the extracellular matrix components.
  • To elucidate the pathogenesis of psychiatric and neurological disorders caused by neuronal migration defects.
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