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Development of Pathogenesis-based Therapeutic Treatments to Diabetic Neuropathy

Project Leader Kazunori Sango

Kazunori Sango


The increase of the number of diabetics has led to specific chronic complications for which countermeasures are urgently needed. Diabetic neuropathy is the complication that occurs with the greatest frequency, and its irritating symptoms such as pain and numbness can be the cause of insomnia and depression, and when allowed to progress to more advanced disease stages can result in serious consequences such as lower limb amputation and lethal arrhythmia.

In this project, we contribute to improving QOL for diabetics and helping them to live longer lives by clarifying the pathogenesis of neurological disorders and establishing effective treatments.


  • To clarify the pathogenesis of diabetic neuropathy using diabetic model animals and culture systems of neurons and Schwann cells
  • To establish an effective neuropathy treatment
  • To verify the effectiveness of a new hypoglycemic drug, a glucagon-like peptide (GLP)-1 receptor agonist, as a therapeutic agent against neuropathy by focusing on its direct protective effect on the nervous system