8 August 2017
Yukiko Yoshida (Ubiquitin Project) published a paper on “Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy” in PNAS.
Lysosomes play a crucial role in autophagy, but damaged lysosomes are also removed by autophagy. The mechanism how lysosomal damage is recognized in cells remained elusive. FBXO27, a substrate-recognition subunit of the SCF ubiquitin ligase complex, binds glycoproteins but localizes in the cytosol. Yoshida et al. reveal that SCFFBXO27 ubiquitinates leaked glycoproteins from the damaged lysosomes, resulting in inducing autophagy.
Yoshida, Y., Yasuda, S., Fujita, T., Hamasaki, M., Murakami, A., Kawawaki, J., Iwai, K., Saeki, Y., Yoshimori, T., Matsuda, N., and Tanaka, K.
Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy.
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8574-8579. doi: 10.1073/pnas.