In the 21st century, one of the main theme is to understand the human longevity and aging as the average lifespan increases enormously, but there are a number of difficult problems for elderly people and society to adapt the aging society. We have a belief that microorganisms are considered to be an excellent model to understand the human longevity and aging as most of the eukaryotic microbial genes are conserved in human. Why unicellular fission yeast can be useful? Actually there are no ideal organisms readily applicable as a model for human aging and longevity. Monkeys most close to human are very expensive to maintain and any experiments may always be challenged for ethical sense. Mouse has the best genetics and molecular and cellular biology, but its life span is only 3 yr. C. elegans has only several weeks of life span so that there remains serious doubt whether any major conclusion drawn by these organisms’ longevity and aging are also valid for human. The past research of budding yeast offered the knowledge for replicative and chronological life span. Study on Sir2 suggests that yeast and human may share similar mechanisms for cellular aging and longevity. We have initiated the cellular longevity and aging of the fission yeast S. pombe using metabolomic analysis. We aim to combine the yeast knowledge with results of human individual metabolomics analysis. I shall describe the strategy of how yeast and human individual metabolomics analyses can be done in the same laboratory and by the same people in collaboration with investigators in University hospitals.