研究業績 of Lipid Metabolism Project

2015年

原著論文

Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi, R., Kambe, N., Kabashima, K., Lambeau, G., Gelb, M.H., and Murakami, M.
The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.
J. Exp. Med., in press (doi:10.1084/jem.20141904), 2015


Vijay, R., Hua, X., Meyerholz, D.K., Miki, Y., Yamamoto, K., Gelb, M.H., Murakami, M., Perlman, S.
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.
J. Exp. Med., in press (doi: 10.1084/jem.20150632), 2015

Gijs, H.L., Willemarck, N., Vanderhoydonc, F., Khan, N. A., Dehairs, J., Derua, R., Waelkens, E., Taketomi, Y., Murakami, M., Agostinis, P., Annaert, W., and Swinnen, J.V.
Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.
Mol. Biol. Cell., 26, 2321-2332, 2015

Kazama, S., Kitayama, J., Hiyoshi, M., Taketomi, Y., Murakami, M., Nishikawa, T., Tanaka, T., Tanaka, J., Kiyomatsu, T., Kawai, K., Hata, K., Yamaguchi, H., Nozawa, H., Ishihara, S, Sunami, E., and Watanabe, T.
Phospholipase A2 group III and group X have opposing associations with prognosis in colorectal cancer.
Anticancer Res., 35, 2983-2990, 2015

Berry, E., Hernandez-Anzaldo, S., Ghomashchi, F., Lehner, R., Murakami, M., Gelb, M.H., Kassiri, Z., Wang, X., and Fernandez-Patron, C.
Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever.
J. Am. Heart Assoc., 4, pii: e001868, 2015

Miyazaki, T., Taketomi, Y., Saito, Y., Hosono, T., Lei, X.F., Kim-Kaneyama, J. R., Arata, S., Takahashi, H., Murakami, M., and Miyazaki, A.
Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.
Circ. Res., 116, 1170-1181, 2015


総説論文

Murakami, M., and Taketomi, Y.
Phospholipase A2.
Bioactive Lipid Mediators, Springer, in press, 2015
eds. Yokomzo, T. and Murakami, M.

Murakami, M., Sato, H., Miki, Y., Yamamoto, K., and Taketomi, Y.
A new era of secreted phospholipase A2.
J. Lipid Res., 56, 1248-1261, 2015

Murakami, M., and Taketomi, Y.
Secreted phospholipase A2s and mast cells.
Allergology Int., 64, 4-10, 2015

武富 芳隆村上 誠
sPLA2と炎症.
炎症と免疫, in press, 2015

村上 誠、横溝 岳彦
脂質疾患学:なぜ“あぶら”の異常が病気を引き起こすのか?.
実験医学増刊, 羊土社, 2015(監修)

久木山 清貴、村上 誠
ホスホリパーゼA2と循環器疾患.
実験医学増刊, 羊土社, 33, 2402-2406, 2015

平林 哲也村上 誠
ホスホリパーゼA2と神経疾患.
実験医学増刊, 羊土社, 33, 2456-2461, 2015

武富 芳隆村上 誠
アレルギーと脂質代謝.
臨床免疫・アレルギー科, 62, 659-667, 2015

尾池 雄一、佐々木 雄彦、村上 誠、矢作 直也
疾患モデルの作製と利用:脂質代謝異常と関連疾患(上・下巻)
seriesモデル動物利用マニュアル, エル・アイ・シー, 2015(企画・編集)

平林 哲也村上 誠
細胞内ホスホリパーゼA2.
seriesモデル動物利用マニュアル, エル・アイ・シー, 147-159, 2015

武富 芳隆村上 誠
分泌性ホスホリパーゼA2.
seriesモデル動物利用マニュアル, エル・アイ・シー, 160-173, 2015

三木 寿美山本 圭村上 誠
接触皮膚炎と抗炎症脂質メディエーター.
臨床免疫・アレルギー科, 63, 156-163, 2015

村上 誠
sPLA2と炎症・免疫.
炎症と免疫, 23, 78-86, 2015

村上 誠
リン脂質からオメガ3脂肪酸を動員するホスホリパーゼA2.
食品と開発, 50, 9-11, 2015


2014年

原著論文

Sato, H., Taketomi, Y., Ushida, A., Isogai, Y., Kojima, T., Hirabayashi, T., Miki, Y., Yamamoto, K., Nishito, Y., Kobayashi, T., Ikeda, K., Taguchi, R., Hara, S., Ida, S., Miyamoto, Y., Watanabe, M., Baba, H., Miyata, K., Oike, Y., Gelb, M.H., and Murakami, M.
The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
Cell Metab., 20, 119-132, 2014


Yoda, E., Rai, K., Ogawa, M., Takakura, Y., Kuwata, H., Suzuki, H., Nakatani, Y., Murakami, M., and Hara, S.
Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice.
PLoS One., 9, e109409, 2014

Hwang, S.K., Lu, Y., Li, X., Kim, Y.D., Cho, Y.S., Jahng, Y., Son, J.K., Lee, Y.J., Kang, W., Taketomi, Y., Murakami, M., Moon, T.C., and Chang, H.W.
ERK1/2 antagonize AMPK-dependent regulation of FcεRI-mediated mast cell activation and anaphylaxis.
J. Allergy Clin. Immunol., 134, 714-721. e7, 2014

Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., Sugimoto, Y.
Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.
J. Immunol., 192, 1130-1137, 2014

Mishina, H., Tamaru, S., Watanabe, K., Watanabe, Y., Fujioka, D., Takahashi, S., Suzuki, K., Nakamura, T., Obata, J., Kawabata, K., Yokota, Y., Inoue, O., Murakami, M., Hanasaki, K., and Kugiyama, K.
Lack of phospholipase A2 receptor increases susceptibility to cardiac rupture after myocardial infarction.
Circ. Res., 114, 493-504, 2014

Udagawa, O., Ito, C., Ogonuki, N., Sato, H., Lee, S., Tripvanuntakul, P., Ichi, I., Uchida, Y., Nishimura, T., Murakami, M., Ogura, A., Inoue, T., Toshimori, K., and Arai, H.
Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family.
Genes Cells, 19, 13–27, 2014


総説論文

Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Yamamoto, K., and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.
Biochimie., 107, 105-113, 2014

武富 芳隆村上 誠
ホスホリパーゼA2によるマスト細胞の制御.
臨床免疫・アレルギー科, 62, 659-667, 2014

武富 芳隆村上 誠
リン脂質シグナル、PLA2と発がん.
The Lipids, 25, 70-78, 2014

武富 芳隆
新たなマスト細胞制御因子の同定と制御メカニズムの発見.
YAKUGAKU ZASSHI, 134, 1179–1189, 2014

佐藤 弘泰村上 誠
リン脂質の質と量の変動が全身の代謝を決める:ホスホリパーゼA2による代謝シグナル.
実験医学増刊—驚愕の代謝システム, 32, 27-33, 2014

武富 芳隆村上 誠
sPLA2を起点とした脂質ネットワークによる免疫制御の新機軸.
生化学, 86, 286-291, 2014

武富 芳隆村上 誠
分泌性ホスホリパーゼA2による免疫制御.
医学のあゆみ, 248, 949-955, 2014


2013年

原著論文

Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., Taguchi, R., Kabashima, K., Arita, M., Arai, H., Lambeau, G., Bollinger, J.M., Hara, S., Gelb, M.H., and Murakami, M.
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.
J. Exp. Med., 210, 1217-1234, 2013


Taketomi, Y., Ueno, N., Kojima, T., Sato, H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M., Nakamura, M., Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M. H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., and Murakami, M.
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Nat. Immunol., 14, 554-563, 2013


Tamaru, S, Mishina, H, Watanabe, Y, Watanabe, K, Fujioka, D, Takahashi S, Suzuki, K, Nakamura, T, Obata, JE, Kawabata, K, Yokota, Y, Murakami, M,, Hanasaki, K, and Kugiyama, K.
Deficiency of phospholipase A2 receptor exacerbates ovalbumin-induced lung inflammation.
J. Immunol., 191,1021-1028, 2013

Morita, Y., Sakaguchi, T., Ikegami, K., Goto-Inoue, N., Hayasaka, T. Hang, V.T., Tanaka, H., Harada, T., Shibasaki, Y., Suzuki, A., Inaba, K., Murakami, M., Setou, M., and Konno, H.
Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.
J. Hepatol., 59, 292-299, 2013

Miki, T., Kaneda, M., Iida, K., Hasegawa, G., Murakami, M., Yamamoto, N., Asou, H., and Kasahara K.
An anti-sulfatide antibody O4 immunoprecipitates sulfatide rafts including Fyn, Lyn and the G protein α subunit in rat primary immature oligodendrocytes.
Glycoconj. J., 30, 819-823, 2013

Lu, Y., Piao, D., Zhang, H., Li, X., Chao, G.H., Park, S.J., Chang, Y.C., Kim, C.H., Murakami, M., Jung, S.H., Choi, J.H., Son, J.K., and Chang, H.W.
Saucerneol F inhibits tumor necrosis factor-α and IL-6 production by suppressing Fyn-mediated pathways in FcεRI-mediated mast cells.
Food Chem. Toxicol., 59C, 696-702, 2013

Lu, Y., Na, M.K., Suh, S.J., Li, X., Kim, G.J., Chao, G.H., Jeong, Y.T., Kim, D.S., Chang, Y.C., Murakami, M., Kang, W., Kim, C.H., and Chang, H.W.
Anti-inflammatory activity of hexane extracts from bones and internal organs of Anguilla japonica suppresses cyclooxygenase-2- dependent prostaglandin D2 generation in mast cells and anaphylaxis in mice.
Food Chem. Toxicol., 57, 307-313, 2013

Ogawa, Y., Taketomi, Y., Murakami, M., Tsujimoto, M., and Yanoshita, R.
Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing.
Biol. Pharm. Bull., 36, 66-75, 2013.

Morita, M., Kuba, K., Ichikawa, A., Nakayama, M., Katahira, J., Iwamoto, R., Watanabe, T., Sakabe, S., Daidoji, T., Nakamura, S., Kadawaki, A., Ohto, T., Nakanishi, H., Taguchi, R., Nakaya, T., Murakami, M., Yoneda, Y., Arai, H., Kawaoka, Y., Penninger, M. J., Arita, M., and Imai, Y.
The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza.
Cell, 153, 112-125, 2013

Hwang, S.L., Li, X., Lu, Y., Jin, Y., Jeong, Y.T., Kim, Y.D., Lee, I.K., Taketomi, Y., Sato, H., Cho, Y.S., Murakami, M., and Chang, H.W.
AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice.
J. Allergy Clin. Immunol., 132, 729-736, 2013

Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N. H., Hongo, K., Kaneko, M., Sunami, E., and Watanabe, T
The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer.
Oncol. Lett., 5, 533-538, 2013

Ait-Oufella, H., Herbin, O., Lahoute, C., Coatrieux, C., Loyer, X., Joffre, J., Laurans, L., Ramkhelawon, B., Blanc-Brude, O., Karabina, S., Girard, C.A., Payré, C., Yamamoto, K., Binder, C. J., Murakami, M., Tedgui, A., Lambeau, G., and Mallat, Z.
Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor–null mice
Arterioscler Thromb. Vasc. Biol., 33, 466-473, 2013


総説論文

Murakami, M. and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: an update.
Biochimie, 95, 43-50, 2013

村上 誠
分泌性ホスホリパーゼA2による免疫制御.
細胞工学, 12, 1265-127, 2013

武富 芳隆村上 誠
脂質メディエーターによるアレルギー制御.
実験医学増刊, 31, 118-128, 2013

三木 寿美山本 圭村上 誠
疾病における脂質代謝ネットワークの機能.
オレオサイエンス, 13, 10: 485-492, 2013

武富 芳隆村上 誠
分泌性ホスホリパーゼA2.
The Lipid, 24, 70-78, 2013

武富 芳隆村上 誠.
脂質ネットワークとアナフィラキシー.
アレルギー・免疫, 20, 8: 38-48, 2013

村上 誠
ホスホリパーゼA2酵素群 最新生理活性脂質研究.
遺伝子医学MOOK, 24, 138-145, 2013(編集)


2012年

原著論文

Nakahigashi, K., Otsuka, A., Doi, H., Hirabayashi, T., Murakami, M., Urade, Y., Tanizaki, H., Egawa, G., Miyachi, Y., and Kabashima, K.
PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis.
J. Allergy Clin. Immunol., 129, 536-543, 2012

Sasaki, Y., Kamei, D., Ishikawa, Y., Ishii, T., Uematsu, S., Akira, S., Murakami, M., and Hara, S.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Oncogene, 31, 2943-2952, 2012

Lu,Y., Suh, S.J., Li, X., Hwang, S.L., Li, Y., Hwangbo, K., Park, S.J., Murakami, M., Lee, S.H., Jahng, Y., Son, J.K., Kim, C.H., and Chang, H.W.
Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells.
Food Chem. Toxicol., 50, 4382-4388, 2012

Lu, Y., Suh, S.J., Li, X., Liang, J.L., Chi, M., Hwangbo, K., Kwon, O., Chung, T.W., Kwak, C.H., Kwon, K.M., Murakami, M., Jahng, Y., Kim, C.H., Son, J.K., and Chang, H.W.
Citreorosein inhibits production of proinflammatory cytokines by blocking mitogen activated protein kinases, nuclear factor-kB and activator protein-1 activation in mouse bone marrow-derived mast cells.
Biol. Pharm. Bull., 35, 938-945, 2012


総説論文

Murakami, M. and Taketomi, Y.
Unraveling the secrets of secreated phopholipase A2.
Trends Cell Mol. Biol., 7, 57-71, 2012

武富 芳隆村上 誠
PLA2.
動脈硬化症の新しい診断・治療標的, 53-64, 2012

武富 芳隆村上 誠
アナフィラキシーを制御する脂質ネットワーク.
臨床免疫・アレルギー科, 550-559, 2012


2011年

原著論文

Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., and Murakami, M.
Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2α, not iPLA2β, to lipid mobilization in proximal mast cells and distal fibroblasts.
J. Biol. Chem., 286, 37249-37263, 2011


Yamamoto, K., Taketomi, Y., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M.
Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin.
J. Biol. Chem., 286, 11616-11631, 2011


Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., and Murakami, M.
Physiological roles of group X secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
J. Biol. Chem., 286, 11632-11648, 2011


Lu , Y., Yang , J.H., Li , X., Hwangbo, K., Hwang , S.L., Taketomi, Y., Murakami, M., Chang, Y.C., Kim, C.H., Son, J.K., and Chang, H.W.
Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation.
Biochem. Pharmacol., 82, 1700-1708, 2011

Miyazaki, T., Taketomi, Y., Takimoto, M.,Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., and Miyazaki, A.
m-Calpain is induced in vascular endothelial cells on human atheroma and accelerates atherosclerotic lesion development through proteolytic disorganization of VE-cadherin in hypercholesterolemic mice.
Circulation, 124, 2522-2532, 2011


総説論文

Murakami, M., Taketomi, Y., Sato, H., Hirabayahshi, T., and Yamamoto, K.
Secreted phospholipase A2 revisited.
J. Biochem., 150, 233-255, 2011

Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayahshi, T., and Yamamoto, K.
Resent progress in phospholipase A2 research: From cells to animals to humans.
Prog. Lipid Res., 50, 152-192, 2011

Murakami, M.
Lipid mediators in life science.
Exp. Anim., 60, 7-20, 2011

Murakami, M., Taketomi, Y., Sato, H., and Yamamoto, K.
Integrated lipidomics in the secreted phospholipase A2 biology.
Int. J. Mol. Sci., 12, 1474-1495, 2011

Yamamoto, K., Isogai, Y., Sato, H., Taketomi, Y., and Murakami, M.
Secreted phospholipase A2, Lipoprotein hydrolysis, and atherosclerosis: integration with lipidomics.
Anal. Bioanal. Chem.,400, 1829-1842, 2011

Taketomi, Y. and Murakami, M.
Phospholipase A2 as a potential target of airway diseases.
Obstructive Airway Diseases: Role of Lipid Mediators, 39-67, 2011

武富 芳隆村上 誠
マスト細胞生物学における脂質代謝ネットワーク.
YAKUGAKU ZASSHI, 131, 73-84, 2011

山本 圭村上 誠
ホスホリパーゼA2.
生化学, 83, 449-461, 2011

村上 誠
ホスホリパーゼA2・シクロオキシゲナーゼ.
生化学辞典, 2011

佐藤 弘泰武富 芳隆山本 圭村上 誠
高脂血症.
生命科学研究の戦略:疾患モデルマウス表現型解析指南, 278-287, 2011


2010年

原著論文

Sato, H., Taketomi, Y., Isogai, Y., Miki, Y., Yamamoto, K., Masuda, S., Hosono, T., Arata, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Nakanishi, H., Ikeda, K., Taguchi, R., Hara, S., Kudo, I., and Murakami, M.
Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice.
J. Clin. Invest., 120, 1400-1414, 2010


Escoffier, J., Jemel, I., Tanemoto, A., Taketomi, Y., Payre, C., Coatrieux, C., Sato, H., Yamamoto, K., Masuda, S., Pernet-Gallay, K., Pierre, V., Hara, S., Murakami, M., De Waard, M., Lambeau, G., and Arnoult, C.
Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice.
J. Clin. Invest., 120, 1415-1428, 2010


Yoda, E., Hachisu, K., Taketomi, Y., Yoshida, K., Nakamura, M., Ikeda, K., Taguchi, R., Nakatani, Y., Kuwata, H., Murakami, M., Kudo, I., and Hara S.
Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of group VIB Ca2+-indpendent phospholipase A2 (iPLA2 gamma) deficient mice.
J. Lipid Res., 51, 3003-3015, 2010


総説論文

Murakami, M., Taketomi, Y., Girard, C., Yamamoto, K., and Lambeau, G.
Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.
Biochimie, 92, 561-582, 2010

Hara, S., Kamei, D., Sasaki, Y., Tanemoto, A., Nakatani, Y., and Murakami, M.
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models.
Biochimie, 92, 651-659, 2010

村上 誠
脂質メタボロームから見るsPLA2群の生体内機能.
遺伝子医学MOOK, 16, 191-196, 2010

村上 誠
分泌性ホスホリパーゼA2.
日薬理誌, 135, 217-218, 2010

武富 芳隆村上 誠
分泌性ホスホリパーゼA2遺伝子改変マウス.
The Lipid, 121, 4-12, 2010

村上 誠佐藤 弘泰平林 哲也,、山本 圭武富 芳隆
ホスホリパーゼA2の生理的・病理的役割.
実験医学増刊, 28, 114-125, 2010


2009年

原著論文

Kamei, D., Murakami, M., Sasaki, Y., Nakatani, Y., Majima, M., Ishikawa, Y., Ishii, T., Uematsu, S., Akira, S., Hara, S., and Kudo, I.
Microsomal prostaglandin E synthase-1in both cancercells and hosts contributes to tumor growth, invasion and metastasis.
Biochem. J., 425, 361-371, 2009

Ishikawa, Y., Kimura-Matsumoto, M., Murakami, M., Yamamoto, K., Akasaka, Y., Uzuki, M., Yuri, Y., Inomata, N., Yokoo, T. and Ishii, T.
Distribution of smooth muscle cells and macrophages expressing scavenger receptor Bi/II in atherosclerosis.
J. Atheroscler. Throm., 16, 829-839, 2009

Sato, H., Taketomi, Y., Isogai, Y., Masuda, S., Kobayashi, T., Yamamoto, K., and Murakami, M.
Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation.
Biochem. J., 421, 17-27, 2009


Nakamura, Y., Kambe, N., Saito, M., Mishikomori, R., Kim, Y.-G., Murakami, M., Nunez, G., and Matsue, H.
Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
J. Exp. Med., 206, 1037-1046, 2009


総説論文

Arata, S., Hosono, T., Taketomi, Y., Kageyama, H., Nakamachi, T., and Shioda, S.
Increased behavioral activity with regular circadian rhythm in PACAP specific receptor (PAC1R) transgenic mice.
Transmitters and Modulators in Health and Disease, Springer-Verlag, 199-205, 2009

横溝 岳彦、村上 誠
概論-脂質メディエーターの機能.
実験医学, 27, 2040-2046, 2009

武富 芳隆佐藤 弘泰村上 誠
アレルギー性疾患における脂質メディエーターの役割.
実験医学, 27, 2074-2079, 2009

山本 圭村上 誠
ホスホリパーゼA2と炎症.
炎症と免疫, 17, 359-365, 2009


2008年

原著論文

Sato, H., Kato, R., Isogai, Y., Saka, G., Ohtsuki, M., Taketomi, Y., Yamamoto, K., Tsutsumi, K., Yamada, J., Masuda, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Ikeda, K., Taguchi, R., Hatakeyama, S., Hara, S., Kudo, I., Itabe, H., and Murakami, M.
Analyses of group III secreted phospholipase A2 transgenic mice reveals potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.
J. Biol. Chem., 283, 33483-33497, 2008.


Ueno, N., Taketomi, Y., Koga, K., Atsumi, Y., Kikuchi-Yanoshita, R., Kudo, I., and Murakami, M.
A negative regulator of delayed prostaglandin D2 production in mouse mast cells.
Biochim. Biophys. Acta, 1781, 415-421, 2008

Masuda, S., Yamamoto, K., Hirabayashi, T., Ishikawa, Y., Ishii, T., Kudo, I., and Murakami, M.
Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival.
Biochem. J., 409, 429-438, 2008

Yamakawa, K., Kamekura, S., Kawamura, N., Saegusa, M., Kamei, D., Murakami, M., Kudo, I., Uematsu, S., Akira, S., Chung, U.I., Nakamura, K., and Kawaguchi, H.
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.
Arthritis Rheum., 58, 172-183, 2008

Takano, H., Nakazawa, S., Okuno, Y., Shirata, N., Tsuchiya, S., Kainoh, T., Takamatsu, S., Furuta, K., Taketomi, Y., Naito, Y., Takamatsu, H., Kozutsumi, Y., Tsujimoto, G., Murakami, M., Kudo, I., Ichikawa, A., Nakayama, K., Sugimoto, Y., and Tanaka, S.
Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells.
FEBS Lett., 582, 1444-1450, 2008

Kimura-Matsumoto, M., Ishikawa, Y., Komiyama, K., Tsuruta, T., Murakami, M., Masuda, S., Akasaka, Y., Ito, K., Ishiguro, S., Morita, H., Sato, S., and Ishii, T.
Expression of secretory phospholipase A2s in human atherosclerosis development.
Atherosclerosis, 196, 81-91, 2008

Shimizu, M., Nakamura, H., Hirabayashi, T., Suganami, A., Tamura, Y., and Murayama, T.
Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2 alpha (cPLA2 alpha) by calmodulin-dependent protein kinase: Possible interaction with catalytic domain A of cPLA2 alpha.
Cell Signal., 20, 815-824, 2008

Shimizu, M., Matsumoto, Y., Kurosawa, T., Azuma, C., Enomoto, M., Nakamura, H., Hirabayahsi, T., Kaneko, M., Okuma, Y., and Murayama, T.
Release of arachidonic acid induced by tumor necrosis factor-alpha in the presence of caspase inhibition: evidence for a cytosolic phospholipase cPLA2 alpha-independent pathway.
Biochem. Pharmacol., 75, 1358-1369, 2008

Mashimo, M., Hirabayashi, T., Murayama, T., and Shimizu, T.
Cytosolic PLA2 alpha activation in purkinje neurons and its role in AMPA-receptor trafficking..
J. Cell Sci., 121, 3015-1024, 2008

Nabemoto, M., Mashimo, M., Someya, A., Nakamura, H., Hirabayashi, T., Fujino, H., Kaneko, M., Okuma, Y., Saito, T., Yamaguchi, N., and Murayama, T.
Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A2 alpha .
Eur. J. Parmacol., 590, 1-11, 2008

Maehama, T., Tanaka, M., Nishina, H., Murakami, M., Kanaho, Y., and Hanada, K.
RalA functions as an indispensable signal mediator for nutrient sensing system.
J. Biol. Chem., 283, 35053-35059, 2008


総説論文

平林 哲也村上 誠
ホスホリパーゼA2と病態.
BioClinica, 23, 50-55, 2008

村上 誠
sPLA2群の生体内機能とメタボロミクス.
炎症・再生, 28, 454-460, 2008

村上 誠
生化学事典第4版, 一部執筆, 2008


2007年

原著論文

Kuwata, H., Fujimoto, C., Yoda, E., Nakatani, Y., Hara, S., Murakami, M., and Kudo, I.
A novel role of group VIB calcium-independent phospholipase A2 (iPLA2 gamma) in the inducible expression of group IIA secretory phospholipase A2 in rat fibroblastic cells.
J. Biol. Chem., 282, 20124-20132, 2007.

Taketomi, Y., Sunaga, K., Tanaka, S., Nakamura, M., Arata, S., Okuda, T., Moon, T.C., Chang, H.W., Sugimoto, Y., Kokame, K., Miyata, T., Murakami, M., and Kudo, I.
Impaired mast cell maturation and degradation and attenuated allergic responses in Ndrg1-deficient mice.
J. Immunol., 178, 7042-7053, 2007


Miki, Y., Mukae, S., Murakami, M., Ishikawa, Y., Ishii, T., Ohki, H., Matsumoto, M., and Komiyama, K.
Butylate inhibits oral cancer cell proliferation and regulates expression of secretory phospholipase A2-X and COX-2.
Anti-Cancer Res., 27, 1493-1502, 2007

Taniguchi, T., Shimizu, M., Nakamura, H., Hirabayashi, T., Fujino, H., Saito, T., and Murayama, T.
Vanadate-induced activation of cytosolic phospholipase A2 alpha in L929 cells; roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase.
Biochem. Pharm., 73, 854-862, 2007


総説論文

村上 誠
脂質の新たな機能を追う.
細胞工学, 11, 2007(監修)

村上 誠
脂質メディエーター研究の現状と展望.
細胞工学, 11, 1218-1220, 2007

山本 圭平林 哲也村上 誠
ホスホリパーゼA2の多様性と機能.
細胞工学, 11, 1221-1226, 2007

村上 誠
脂質メタボロームから見た動脈硬化.
BioClinica, 22, 80-85, 2007

村上 誠
メタボリックシンドロームにおける脂質代謝異常と血管障害/ホスホリパーゼA2群の代謝機能を中心に.
血管医学, 8, 17-24, 2007

亀井 大輔、工藤 一郎、村上 誠
COX-2の下流で機能する膜結合型PGE合成酵素(mPGES-1)
治療学, 41, 40-44, 2007


2006年

原著論文

Ohtsuki, M., Taketomi, Y., Arata, S., Masuda, S., Ishikawa, Y., Ishii, T., Takanezawa, Y., Aoki, J., Arai, H., Yamamoto, K., Kudo, I., and Murakami. M.
Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction.
J. Biol. Chem., 281, 36420-36433, 2006


Wijewickrama, G.T., Albanese, A., Kim, Y.J., Oh, Y.S., Murray, P.S., Takayanagi, R., Tobe, T., Masuda, S., Murakami, M., Kudo, I., Ucker, D. S., Murray, D., and Cho, W.
Unique membrane interaction mode of group IIF phospholipase A2.
J. Biol. Chem., 281, 32741-32754, 2006

Mitsuishi, M., Masuda, S., Kudo, I., and Murakami, M.
Group V and X secretory phospholipase A2s prevent adenovirus infection into mammalian cells.
Biochem. J., 393, 97-106, 2006

Okahara, F., Itoh, K., Nakagawara, A., Murakami, M., Kanaho, K., and Maehama, T.
Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.
Mol. Biol. Cell., 17, 4888-4895, 2006

Taniguchi, T., Shimizu, M., Nakamura, H., Hirabayashi, T., Fujino, H., and Murayama, T.
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2 alpha.
Eur. J. Pharmacol., 546, 1–10, 2006

Akiyama, N., Nabemoto, M., Hatori, Y., Nakamura, H., Hirabayashi, T., Fujino, H., Saito, T., and Murayama, T.
Up-reguration of cytosolic phospholipase A2 alpha expression by N,N-dimethyldithiocarbamate in PC12 cells; involvement of reactive oxygen species and nitric oxide.
Toxicol. Appl. Pharmacol., 215, 218–227, 2006

Nakamura, H., Hirabayashi, T., Shimizu, M., and Murayama, T.
Ceramide-1-phosphate activates cytosolic phospholipase A2 alpha directly and by PKC pathway.
Biochem. Pharmacol., 71, 850–857, 2006


総説論文

Murakami, M. and Kudo, I.
Prostaglandin E syhthase: a novel drug target for inflammation and cancer.
Curr. Pharm. Des., 12, 943-954, 2006

平林 哲也
肝臓におけるコレステロール合成のフィードバック制御.
ファルマシア, 42, 369-370, 2006

上野 紀子村上 誠
マスト細胞とアラキドン酸代謝.
アレルギー・免疫, 13, 58-64, 2006


2005年

原著論文

Kubota, K., Kubota, K., Kamei, D., Murakami, M., Kudo, I., Aso, I., Morita, I.
Change in prostaglandin E synthases (PGESs) in microsomal PGES-1 knockout mice in a preterm delivery model.
J. Endocrinol., 187, 339-345, 2005

Ishikawa, Y., Komiyama, I., Masuda, S., Murakami, M., Akasaka, Y., Ito, K., Akishima, Y., Kimura, M., Fujimoto, A., Kudo, I., Ishii, T.
Expression of type V secretory phospholipase A2 in myocardial remodeling after infarction.
Histopathology, 47, 257-267, 2005

Masuda, S., Murakami, M., Mitsuishi, M., Komiyama, K., Ishikawa, Y., Ishii, T., Kudo, I.
Expression of secretory phospholipase A2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells.
Biochem. J., 387, 27-38, 2005

Masuda, S., Murakami, M., Ishikawa, Y., Ishii, T., Kudo, I.
Diverse cellular localizations of secretory phospholipase A2 enzymes in several human tissues.
Biochim. Biophys. Acta, 1736, 200-210, 2005

Masuda, S., Murakami, M., Komiyama, K., Ishihara, M., Ishikawa, Y., Ishii, T., Kudo, I.
Various secretory phospholipase A2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells.
FEBS J., 272, 655-672, 2005

Kuwata, H., Nonaka, T., Murakami, M., Kudo, I.
Search of factors that intermediate cytokine-induced group IIA phospholipase A2 expression through the cytosolic phospholipase A2- and 12/15-lipoxygenase-dependent pathway.
J. Biol. Chem., 280, 25830-25839, 2005

Murakami, M., Masuda, S., Shimbara, S., Ishikawa, Y., Ishii, T., Kudo, I.
Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A2.
J. Biol. Chem., 280, 24987-24998, 2005

Masuda, S., Murakami, M., Takanezawa, Y., Aoki, J., Arai, H., Ishikawa, Y., Ishii, T., Arioka, M., Kudo, I.
Neuronal expression and neuritogenic action of group X secreted phospholipase A2.
J. Biol. Chem., 280, 23203-23214, 2005

Murakami, M., Masuda, S., Ueda-Semmyo, K., Yoda, E., Kuwata, H., Takanezawa, Y., Aoki, J., Arai, H., Sumimoto, H., Ishikawa, Y., Ishii, T., Nakatani, Y., Kudo, I.
Group VIB Ca2+-independent phospholipase A2 (iPLA2 gamma) promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipase A2s.
J. Biol. Chem., 280, 14028-14041, 2005

Okahara, F., Itoh, K., Ebihara, M., Kobayashi, M., Maruyama, H., Kanaho, Y., Maehama, T.
Production of research-grade antibody by in vivo electroporation of DNA-encoding target protein.
Anal. Biochem., 336, 138-140, 2005

Sasaki, J., Sasaki, T., Yamazaki, M., Matsuoka, K., Taya, C., Shitara, H., Takasuga, S., Nishio, M., Mizuno, K., Wada, T., Miyazaki, H., Watanabe, H., Iizuka, R., Kubo, S., Murata, S., Chiba, T., Maehama, T., Hamada, K., Kishimoto, H., Frohman, M. A., Tanaka, K., Penninger, J. M., Yonekawa, H., Suzuki, A., and Kanaho, Y.
Regulation of anaphylactic response by phosphatidylinositol phosphate kinase type Ia.
J. Exp. Med., 201,859-870,2005

Miyazaki, H., Yamazaki, M., Watanabe, H., Maehama, T., Yokozeki, T.,Kanaho, Y.
The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.
FEBS Lett., 579, 6834-6838, 2005


総説論文

Ueno, N., Takegoshi, Y., Kamei, D., Kudo, I., and Murakami, M.
Coupling between cyclooxygenasesand terminal prostanoid synthases.
Biochem. Biophys. Res. Commun., 338, 70-76, 2005

Kudo, I. and Murakami, M.
Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis..
J. Biochem. Mol. Biol., 38, 633-638, 2005

村上 誠、工藤 一郎
ホスホリパーゼA2研究の展開.
実験医学, 23, 878-885, 2005

上野 紀子村上 誠
マスト細胞と脂質メディエーター.
アレルギー科, 20, 281-290, 2005

村上 誠、青木 淳賢
脂質シグナリングのフロンティア.
薬事日報, 9856, 11, 2005