研究業績

  1. Shimada T and Yamagata K. Pentylenetetrazole-induced kindling mouse model. JoVE, 12;(136), 2018.
  2. Azuchi Y, Namekata K, Shimada T, Guo X, Kimura A, Harada C, Saito A, Yamagata K, Harada T. Role of neuritin in retinal ganglion cell death in adult mice following optic nerve injury. Sci. Rep. 8(1):10132, 2018.
  3. Takemiya T, Fumizawa K, Yamagata K, Iwakura Y, Kawakami M. Brain interleukin-1 facilitates learning of a water maze spatial memory task in young mice. Front Behav Neurosci., 11:202, 2017.
  4. Shimada T, Yoshida T, Yamagata K. Neuritin Mediates Activity-Dependent Axonal Branch Formation in Part via FGF Signaling. J Neurosci. 36(16):4534-48, 2016.
  5. Sugiura H, Yasuda S, Katsurabayashi S, Kawano H, Endo K, Takasaki K, Iwasaki K, Ichikawa M, Kobayashi T, Hino O, Yamagata K. Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex. Nat Commun. 6:6842, 2015.
  6. Masui K, Tanaka K, Ikegami S, Villa GR, Yang H, Yong WH, Cloughesy TF, Yamagata K, Arai N, Cavenee WK, Mischel PS. Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance. Proc Natl Acad Sci U S A. 112(30):9406-11, 2015.
  7. Yasuda S, Sugiura H, Katsurabayashi S, Shimada T, Tanaka H, Takasaki K, Iwasaki K, Kobayashi T, Hino O, Yamagata K. Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex. Sci Rep. 4:5155, 2014.
  8. Shimada T, Takemiya T, Sugiura H, Yamagata K. Role of Inflammatory mediators in the pathogenesis of epilepsy. Mediators Inflamm. 2014:901902, 2014.
  9. Oda A, Yamagata K, Nakagomi S, Uejima H, Wiriyasermkul P, Ohgaki R, Nagamori S, Kanai Y, Tanaka H. Nicotine induces dendritic spine remodeling in cultured hippocampal neurons. J Neurochem. 128(2):246-55, 2014.
  10. Shimada T, Fournier AE, Yamagata K. Neuroprotective function of 14-3-3 proteins in neurodegeneration. Biomed Res Int. 2013:564534, 2013.
  11. Kim SY, Yasuda S, Tanaka H, Yamagata K, Kim H. Non-clustered protocadherin. Cell Adh Migr. 5(2):97-105, 2011.
  12. Takemiya T, Matsumura K, Sugiura H, Yasuda S, Uematsu S, Akira S, Yamagata K. Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels. Neurochem Int. 58(4):489-96, 2011.
  13. Takemiya T, Matsumura K, Sugiura H, Maehara M, Yasuda S, Uematsu S, Akira S, Yamagata K. Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate. J Neurosci Res. 88:381-90, 2010.
  14. Yasuda S, Sugiura H, Yamagata K: Mek3. UCSD-Nature Molecule Pages doi:10.1038/mp.a001507.01, 2009.
  15. Sugiura H, Tanaka H, Yasuda S, Takemiya T, Yamagata K: Transducing neuronal activity into dendritic spine morphology: new roles for p38 MAP kinase and N-cadherin. Neuroscientist 15:90-104, 2009
  16. Yasuda S, Tanaka H, Sugiura H, Okamura K, Sakaguchi T, Tran U, Takemiya T, Mizoguchi A, Yagita Y, Sakurai T, De Robertis EM, Yamagata K: Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases. Neuron 56:456-471, 2007
  17. Sasaki T, Kitagawa K, Yamagata K, Takemiya T, Tanaka S, Omura-Matsuoka E, Sugiura S, Matsumoto M, Hori M: Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice. J. Cereb. Blood Flow Metab. 24:107-13, 2004
  18. Sugiura H, Iwata K, Matsuoka M, Hayashi H, Takemiya T, Yasuda S, Ichikawa M, Yamauchi T, Mehlen P, Haga T, Yamagata K: Inhibitory Role of Endophilin 3 in Receptor-mediated Endocytosis. J. Biol. Chem. 279:23343-23348, 2004
  19. Matsumura K, Yamagata K, Takemiya T, Kobayashi S: COX-2 and mPGES in bain endothelial cells: potential targets of anti-inflammatory. Curr. Med. Chem. 1:161-166, 2002
  20. Yamagata K, Matsumura K, Inoue W, Shiraki T, Suzuki K, Yasuda S, Sugiura H, Cao C, Watanabe Y, Kobayashi S: Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J. Neurosci. 21:2669-2677, 2001
  21. Irie Y, Yamagata K, Gan Y, Miyamoto K, Do E, Kuo CH, Taira E, Miki N: Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells. J. Biol. Chem. 275(4):2647-2653, 2000
  22. Yamagata K, Andreasson KI, Sugiura H, Maru E, Dominique M, Irie Y, Miki N, Hayashi Y, Yoshioka M, Kaneko K, Kato H, Worley PF: Arcadlin is a neural activity-regulated cadherin involved in long term potentiation. J. Biol. Chem. 274:19473-19479, 1999
  23. Saitoh O, Kubo Y, Odagiri M, Ichikawa M, Yamagata K, Sekine T: RGS7 and RGS8 differentially accelerate G Protein-mediated modulation of K+ currents. J. Biol. Chem. 214:9899-9904, 1999
  24. Lyford GL*, Yamagata K*, Kaufmann WE*, Barnes CA, Sanders LK, Copeland NG, Gilbert DJ, Jenkins NA, Lanahan AA, Worley PF: Arc, growth Factor and Activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14:433-445, 1995 ( *equal contribution)
  25. Yamagata K, Kaufmann WE, Lanahan A, Papapavlou M, Barnes CA, Andreasson KI, Worley PF. Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268. Learn Mem. 1(2):140-52, 1994.
  26. Yamagata K, Sanders LK, Kaufmann WE, Yee W, Barnes CA, Nathans D, Worley PF: rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. J Biol Chem. 269(23):16333-9, 1994
  27. Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, Worley PF: Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11(2):371-86, 1993
  28. Yamagata K, Goto K, Kuo CH, Kondo H, Miki N: Visinin: a novel calcium binding protein expressed in retinal cone cells. Neuron 4(3):469-76, 1990

最近の日本語総説

  1. 山形要人 島田忠之 杉浦弘子、自閉症におけるシナプス異常の新知見、月刊「細胞」50:731-734, 2018.
  2. 山形要人 薬理学研究のすすめ、日本薬理学雑誌147:3-4, 2016.
  3. 山形要人、杉浦弘子、安田新 神経活動によるスパイン形態制御と脳疾患、日本薬理学雑誌142: 106-111, 2013.

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