2006年〜2010年

  • Ishiguro H, Koga M, Horiuchi Y, Noguchi E, Morikawa M, Suzuki Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T. Supportive evidence for reduced expression of GNB1L in schizophrenia. Schizophr Bull 36:756-765 2010
  • Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T,Itokawa M, Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia. Arch Gene Psychiatry 67:589-597 2010
  • Itokawa M, Arinami T, Toru M. Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Ser311Cys Polymorphisms of the Dopamine D(2)-Receptor Gene and Schizophrenia. J Pharmacol Sci 114:1-5 2010
  • Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I. The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population. Behav Brain Funct 6:50, 2010
  • Arai M, Itokawa M. A hard road in psychiatric genetics: schizophrenia and DPYSL2. J Hum Genet 55:397-399 2010
  • Yazaki S, Koga M, Ishiguro H, Inada T, Ujike H, Itokawa M, Otowa T, Watanabe Y, Someya T, Iwata N, Kunugi H, Ozaki N, Arinami T. An association study between the dymeclin gene and schizophrenia in the Japanese population. J Hum Genet 55:631-634 2010
  • Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa M, Inada T, Watanabe Y, Takahashi M, Someya T, Ujike H, Iwata N, Ozaki N, Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani S, Naka I, Ohashi J, Kakita A, Takahashi H, Nawa H, Arinami T Brain cannabinoid CB2 receptor in schizophrenia. Biol Psychiatry 67:974-982 2010
  • Takayanagi Y, Kawasaki Y, Nakamura K, Takahashi T, Orikabe L, Toyoda E, Mozue Y, Sato Y, Itokawa M, Yamasue H, Kasai K, Kurachi M, Okazaki Y, Matsushita M, Suzuki M. Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables. Prog Neuropsychopharmacol Biol Psychiatry 34:10-17 2010
  • Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T. Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia. Neuropsychopharmacology 35:1155-1164 2010
  • Takayanagi Y, Takahashi T, Orikabe L, Masuda N, Mozue Y, Nakamura K, Kawasaki Y, Itokawa M, Sato Y, Yamasue H, Kasai K, Okazaki Y, Suzuki M. Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia. Schizophr Res 121:55-65 2010
  • Nozaki I, Arai M, Takahashi K, Hamaguchi T, Yoshikawa H, Muroishi T, Noguchi-Shinohara M, Ito H, Itokawa M, Akiyama H, Kawata A, Yamada M Familial ALS with G298S mutation in TARDBP: A comparison of CSF tau protein levels with those in sporadic ALS. Inter Med 49:1209-1212 2010
  • Koga M, Ishiguro H, Horiuchi Y, Inada T, Ujike H, Itokawa M, Otowa T, Watanabe Y, Someya T, Arinami T Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia. Psychiatr Genet 20:123-125 2010
  • Amagane H, Watanabe Y, Kaneko N, Nunokawa A, Muratake T, Ishiguro H, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Hashimoto R, Itokawa M, Ozaki N, Someya T Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study. Schizophr Res 118:106-112 2010
  • Tamaoka A, Arai M, Itokawa M, Arai T, Hasegawa M, Tsuchiya K, Takuma H, Tsuji H, Ishii A, Watanabe M, Takahashi Y, Goto J, Tsuji S, Akiyama H TDP-43 M337V Mutation in Familial Amyotrophic Lateral Sclerosis in Japan. Intern Med 49:331-334 2010
  • Nunokawa A, Watanabe Y, Kaneko N, Sugai T, Yazaki S, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Itokawa M, Ozaki N, Hashimoto R, Someya T The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: Case-control studies and an updated meta-analysis. Schizophr Res 116:61-67 2010
  • Doi N, Hoshi Y, Itokawa M, Usui C, Yoshikawa T, Tachikawa H. Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint. PLoS One 4(11):e7799 2009
  • Koga M, Ishiguro H, Yazaki S, Horiuchi Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Muchardt C, Yaniv M, Arinami T. Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia. Hum Mol Genet 2483-2494 2009
  • Nishida A, Sasaki T, Nishimura Y, Tanii H, Hara N, Inoue K, Yamada T, Takami T, Shimodera S, Itokawa M, Asukai N, Okazaki Y. Psychotic-like experiences are associated with suicidal feelings and deliberate self-harm behaviors in adolescents aged 12-15 years. Acta Psychiatr Scand121:301-307 2010
  • Watanabe Y, Nunokawa A, Kaneko N, Arinami T, Ujike, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T. Two-stage case-control association study of PADI2 with schizophrenia. J Hum Genet 54:430-432 2009
  • Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T. Preliminary Genome-wide Association Study of Bipolar Disorder in the Japanese Population. Am J Med Genet 150B:1110-1117 2009
  • 糸川昌成, 数藤由美子, 新井誠, 本多真. 統合失調症の遺伝子研究による病態解明: 稀な症例を出発点とするこころみ. 精神医学 51:185-193 2009
  • Ishiguro H, Koga M, Horiuchi Y, Noguchi E, Morikawa M, Suzuki Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T. Supportive evidence for reduced expression of GNB1L in schizophrenia. Schizophr Bull 36:756-765 2010
  • 河上緒、梅津寛、大澤達哉、石川陽一、小椋哲、合川勇三、糸川昌成、岡崎祐士 網膜色素変性症と統合失調症を合併した兄弟例. 東京精神医学会誌27:21-25 2009
  • Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T. Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia. J Hum Genet 54:62-65 2009
  • Ishiguro H, Imai K, Koga M, Horiuchi Y, Inada T, Iwata N, Ozaki N, Ujike H, Itokawa M, Kunugi H, Sasaki T, Watanabe Y, Someya T, Arinami T. Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia. Psychiatr Genet 18:255-256 2008
  • Mizuguchi T, Hashimoto R, Itokawa M, Sano A, Shimokawa O, Yoshimura Y, Harada N, Miyake N, Nishimura A, Saitsu H, Sosonkina N, Niikawa N, Kunugi H, Matsumoto N. Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia. J Hum Genet 53:914-919 2008
  • Nunokawa A, Watanabe Y, Kitamura H, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Ozaki N, Someya T. Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia. Psychiatry Clin Neurosci 62:239-240 2008
  • Li B, Yamamori H, Tatebayashi Y, Shafit-Zagardo B, Tanimukai H, Chen S, Iqbal K, *Grundke-Iqbal I. Failure of neuronal maturation in Alzheimer disease dentate gyrus. J Neuropathol Exp Neurol 67:78-84 2008
  • Ohtsuki T, Koga M, Ishiguro H, Horiuchi Y, Arai M, Niizato K, Itokawa M, Inada T, Iwata N, Iritani S, Ozaki N, Kunugi H, Ujike H, Watanabe Y, Someya T, Arinami T. A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia. Schizophr Res 101:9-16 2008
  • Inoue S, Imamura A, Okazaki Y, Yokota H, Arai M, Hayashi N, Furukawa A, Itokawa M, Oishi M. Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia. Am J Med Genet B Neuropsychiatr Genet 144:332-340 2007
  • Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, Yu WH, Luchsinger JA, Wadzinski B, Duff KE, *Takashima A. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci 27:13635-13648 2007
  • Nakatani N, Ohnishi T, Iwamoto K, Watanabe A, Iwayama Y, Yamashita S, Ishitsuka Y, Moriyama K, Nakajima M, Tatebayashi Y, Akiyama H, Higuchi T, Kato T, *Yoshikawa T. Expression analysis of actin-related genes as an underlying mechanism for mood disorders. Biochem Biophys Res Commun 352:780-786 2007
  • Arai M, Obata N, Kockelkorn TJP, Yamada K, Toyota T, Haga S, Yoshida Y, Ujike H, Sora I, Ikeda K, Yoshikawa T, Itokawa M: Lack of association between polymorphisms in the 5’ upstream region of the DISC1 gene and mood disorders. Psychiat Genet 17:357 2007
  • Itokawa M, Iwata K, Takahashi M, Sugihara G, Sasaki T, Abe Y, Uno M, Hobo M, Jitoku D, Inoue K, Arai M, Yasuda I, Shintani M. Acute confusional state after designer tryptamine abuse Psychiat. Clinic. Neurosci 61:196-199 2007
  • 藤田俊之, 高橋美佐子, 新井誠, 安田一郎, 林直樹, 糸川昌成. 5-MeO-DIPTにより急性再燃をきたした覚醒剤精神病の1例. 精神医学49(1):59-61 2007
  • Fukuda Y, Koga M, Arai M, Noguchi E, Ohtsuki T, Horiuchi Y, Ishiguro H, Niizato K, Iritani S, Itokawa M, Arinami T. Monoallelic and Unequal Allelic Expression of the HTR2A Gene in Human Brain and Peripheral Lymphocytes. Biol Psychiatry 60(12):1331-1335 2006
  • Tatebayashi Y, Planel E, Chui DH, Sato S, Miyasaka T, Sahara N, Murayama M, Kikuchi N, Yoshioka K, Rivka R, *Takashima A. c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis. FASEB J 20:762-764 2006(査読有)
  • Tanemura K, Chui DH, Fukuda T, Murayama M, Park JM, Akagi T, Tatebayashi Y, Miyasaka T, Kimura T, Hashikawa T, Nakano Y, Kudo T, Takeda M, *Takashima A. Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). J Biol Chem 281:5037-5041 2006
  • Doi N, Itokawa M, Hoshi Y, Arai M, Furukawa A, Ujike H, Sora I, Yoshikawa T. A resistance gene in disguise for schizophrenia? Am J Med Genet Part B 144B(2):165-173 2006
  • Yoshitsugu K, Yamada K, Toyota T, Aoki-Suzuki M, Minabe Y, Nakamura K, Sekine Y, Suzuki K, Takei N, Itokawa M, Mori M, Yoshikawa T: Novel scale including strabismus and 'cuspidal ear' for distinguishing schizophrenia patients from controls using minor physical anomalies. Psychiatry Research 145(2-3):249-258 2006
  • Kobayashi H, Hata H, Ujike H, Harano M, Inada T, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Ozaki N, Itokawa M, Naka M, Ide S, Ikeda K, Numachi Y. Association analysis of dopioid receptor gene polymorphisms in methamphetamine dependence/psychosis. Am J Med Genet B Neuropsychiatr Genet 141(5):482-486 2006
  • Ide S, Kobayashi H, Ujike H, Ozaki N, Sekine Y, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Iwata N, Tanaka K, Shen H, Iwahashi K, Itokawa M, Minami M, Satoh M, Ikeda K, Sora I. Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms. Pharmacogenomics J 6(3):179-188 2006
  • Arai M, Yamada K, Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T, Itokawa M. Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia. Biol Psychiatry 59(7):652-659 2006
  • Horiuchi Y, Arai M, Niizato K, Iritani S, Noguchi E, Ohtsuki T, Koga M, Kato T, Itokawa M, Arinami T. A Polymorphism in the PDLIM5 Gene Associated with Gene Expression and Schizophrenia. Biol Psychiatry 59(5):434-439 2006
  • Iwayama Y, Hashimoto K, Nakajima M, Toyota T, Yamada K, Shimizu E, Itokawa M, Hoshika K, Iyo M, Yoshikawa T. Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes. Neurosci Lett 394(2):101-104 2006
  • Hiroi N, Zhu H, Lee MS, Funke B, Sawamura T, Arai M, Itokawa M, Kucherlapati R, Morrow B, Agatsuma S. A 200-kb region of human chromosome 22q11confers schizophrenia-related behavioral abnormalities in mice. Proc Natl Acad Sci U S A. 102:19132-19137, 2005
  • Itokawa M. (40) Genome-wide High-Density SNP Linkage Analysis of 236 Japanese Families Supports the Existence of Schizophrenia Susceptibility Loci on Chromosomes 1p, 14q, and 20p. Am. J. Hum. Genet. 77:937-944, 2005
  • Yamada K, Ohnishi T, Hashimoto K, Ohba H, Iwayama-Shigeno Y, Toyoshima M, Okuno A, Takao H, Toyota T, Minabe Y, Nakamura K, Shimizu E, Itokawa M, Mori N, Ito M, Yoshikawa T. Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels. Biol Psychiatry. 57:1493-1503, 2005
  • Iwayama-Shigeno Y, Yamada K, Itokawa M, Toyota T, Meerabux JM, Minabe Y, Mori N, Inada T, Yoshikawa T. Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia. Neurosci Lett. 378:102-105, 2005