Y. Nakayama, N. Nara, Y. Kawakita, Y. Takeshima, M. Arakawa, M. Katoh, S. Morita, K. Iwatsuki, K. Tanaka, S. Okamoto, T. Kitamura, N. Seki, R. Matsuda, M. Matsuo, K. Saito, and T. Hara. 2004. Cloning of cDNA Encoding a Regeneration-associated Muscle Protease Whose Expression is Attenuated in Cell Lines Derived from Duchenne Muscular Dystrophy Patients. Am. J. Pathol., 164: 1773-1782.
K. Tamura, T. Hara, M. Kutsukake, K. Iwatsuki, M. Yanagida, M. Yoshie, and H. Kogo. 2004. Expression and the biological activities of Insulin-Like Growth Factor-Binding Protein Related Protein 1 in rat uterus during the periimplantation period. Endocrinol., 145: 5243-5251.
M. Arakawa, M. Shiozuka, Y. Nakayama, T. Hara, M. Hamada, D. Ikeda, Y. Takahashi, R. Sawa, Y. Nonomura, K. Sheykholeslami, K. Kondo, K. Kaga, S. Takeda, and R. Matsuda. 2003. Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice. J. Biochem. 134: 751-758.
N. Minegishi, N. Suzuki, T. Yokomizo, X. Pan, T. Fujimoto, S. Takahashi, T. Hara, A. Miyajima, S. Nishikawa, and M. Yamamoto. 2003. Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos. Blood 102: 896-905.
T. Sakurai, K. Tamura, S. Okamoto, T. Hara, and H. Kogo. 2003. Possible role of cyclooxygenase II in the acquisition of ovarian luteal function in rodents. Biol. Reprod. 69: 835-842.
K. Tamura, T. Hara, M. Yoshie, S. Irie, A. Sobel, and H. Kogo. 2003. Enhanced expression of uterine stathmin during the process of implantation and decidualization in rats. Endocrinol. 144: 1464-1473.
H. Tamura, S. Okamoto, K. Iwatsuki, Y. Futamata, K. Tanaka, Y. Nakayama, A. Miyajima, and T. Hara. 2002. In vivo differentiation of stem cells in the aorta-gonad-mesonephros region of mouse embryo and adult bone marrow. Exp. Hematol. 30: 957-966.
K. Tanaka, H. Tamura, H. Tanaka, M. Katoh, Y. Futamata, N. Seki, Y. Nishimune, and T. Hara. 2002. Role of spermatogonia in the regulation of testicular gene expression. Dev. Biol. 246: 466-479.
K. Minehata, Y. Mukouyama, T. Sekiguchi, T. Hara, and A. Miyajima. 2002. Macrophage-colony stimulating factor modurates the development of hematopoiesis by stimulating the differentiation of endothelial cells in the AGM region. Blood 99: 2360-2368.
M. Takeuchi, T. Sekiguchi, T. Hara, T. Kinoshita, and A. Miyajima. 2002. Cultivation of AGM-derived hematopoietic stem cells in the fetal liver microenvironment amplifies long-term repopulating activity and enhances engraftment to the bone marrow. Blood 99: 1190-1196.
M. Arakawa, Y. Nakayama, T. Hara, M. Shiozuka, S. Takeda, K. Kaga, S. Kondo, S. Morita, T. Kitamura, and R. Matsuda. 2001. Negamycin can restore dystrophin in mdx skeletal muscle. Acta Myologica 20: 154-158.
T. Hara, K. Nakayama, and A. Miyajima. 2000. Hematopoietic signal transduction. In Developmental Biology of Hematopoiesis , ed: L. Zon, Oxford University Press, New York. p258-268.
K. Tamura, T. Kawaguchi, T. Hara, S. Takatoshi, A. Tohei, A. Miyajima, T. Seishi, and H. Kogo. 2000. Interleukin-6 decreases estrogen production and messenger ribonucleic acid expression encoding aromatase during in vitro cytodifferentiation of rat granulosa cell. Mol.Cell Endocrinol. 170: 103-111.
Y. Mukouyama, N. Chiba, T. Hara, H. Okada, Y. Itoh, R. Kanamaru, A. Miyajima, M.Satake, and T. Watanabe. 2000. The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region. Dev. Biol. 220: 27-36.
T. Hara, Y. Nakano, M. Tanaka, K. Tamura, T. Sekiguchi, K. Minehata, N. G. Copeland, N. A. Jenkins, M. Okabe, H. Kogo, Y. Mukouyama, and A. Miyajima. 1999. Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region. Immunity 12: 567-578.
M. Tanaka, T. Hara, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, and A. Miyajima. 1999. Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. Blood. 93: 804-815.
Y. Mukouyama, N. Chiba, M.L. Mucenski, M. Satake, A. Miyajima, T. Hara, and T. Watanabe. 1999. Hematopoietic cells in cultures of the murine embryonic aorta-gonad-mesonephros region are induced by c-Myb. Curr. Biol. 9: 833-836.
K. Nakayama, T. Hara, M. Hibi, T. Hirano, and A. Miyajima. 1999. A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth. J. Biol. Chem. 274: 24766-24772.
A. Miyajima, T. Kinoshita, and T. Hara. 1999. Role of the common beta subunit of the interleukin-3, interleukin-5, and granulocyte macrophage-colony stimulating factor receptors. In Interleukin-5/From molecule to drug target for Asthma, ed: C. J. Sanderson, Marcel Dekker, Inc., NewYork. p225-239.
K. Kitajima, M. Kojima, K. Nakajima, S. Kondo, T. Hara, A. Miyajima, and T. Takeuchi. 1999. Definitive but not primitive hematopoiesis is impaired in jumonji. mutant mice. Blood. 93: 87-95.
T. Hara and A. Miyajima. 1998. Cytokine receptors and signal transduction. In Textbook of malignant Haematology, ed: L. Degos, F. Herrman, D. Linch, and B. Lowenberg, Martin Dunitz Ltd., London. p111-131.
T. Hara, K. Tamura, M. P. de Miguel, Y. Mukouyama, H.-j. Kim, H. Kogo, P. J. Donovan, and A. Miyajima. 1998. Distinct roles of oncostatin M and leukemia inhibitory factor in the development of primordial germ cells and Sertoli cells in mice. Dev. Biol. 201:144-153.
M.-j. Xu, K. Tsuji, T. Ueda, Y. Mukouyama, T. Hara, F.-C. Yang, Y. Ebihara, S. Matsuoka, A. Manabe, A. Kikuchi, M. Ito, A. Miyajima, and T. Nakahata. 1998. Stimulation of mouse and human primitive hematopoiesis by murine embryonic Aorta-Gonad-Mesonephros-derived stromal cell lines. Blood 92:2032-2040.
T. Furusawa, N. Yanai, T. Hara, A. Miyajima, and M. Obinata. 1998. Integrin-associated protein (IAP, also termed CD47) is invovled in stroma-supported erythropoiesis. J. Biochem. 123:101-106
Y. Mukouyama, T. Hara, M.-j. Xu, K. Tamura, P. J. Donovan, H.-j. Kim, H. Kogo, K. Tsuji, T. Nakahata, and A. Miyajima. 1998. In vitro expansion of murine multipotential hematopoietic progenitors derived from the embryonic aorta-gonad-mesonephros region. Immunity 8:105-114
T. Hara, M. Ichihara, and A. Miyajima. 1997. Functional difference of the oncostatinM receptor between human and mouse. In Leukocyte Typing VI , ed: T. Kishimoto, H. Kikutani, A. E. G. K. von dem Borne, S. M. Goyert, D. Y. Mason, M. Miyasaka, L. Moretta, K. Okumura, S. Shaw, T. A. Springer, K. Sugamura, H. Zola, Garland Publishing, Inc., New York. p850-851.
C. D. Richards, C. Kerr, M. Tanaka, T. Hara, A. Miyajima, D. Pennica, F. Botelho, and C. L. Langdon. 1997. Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6. J. Immunol. 159:2431-2437
M. Ichihara, T. Hara, H. Kim, T. Murate, and A. Miyajima. 1997. Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice. Blood 90: 165
T. Hara and A. Miyajima. 1996. Function and Signal transduction mediated by the interleukin-3 receptor system in hematopoiesis. Stem Cells 14: 605-618.
T. Hara and A. Miyajima. 1996. Function of the IL-3 receptor system in hematopoiesis. in Gene Technology-Stem Cell and Leukemia Research, NATO ASI Series, ed: A. R. Zander, W. Ostertag, B. V. Afanasiev, F. Grosveld, Springer-Verlag, Berlin Heidelberg. p295-306.
Y. Morikawa, K. Tohya, T. Hara, T. Kitamura, and A. Miyajima. 1996. Expression of IL-3 receptor in testis. Biochem. Biophys. Res. Commun. 226: 107-112.
N. Miura, N. Ishida, M. Hoshino, M. Yamauchi, T. Hara, D. Ayusawa, and M. Kawakita. 1996. Human UDP-galactose translocator: Molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator. J. Biochem. 120: 236-241.
A. Yoshimura, M. Ichihara, I. Kinjyo, M. Moriyama, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, T. Hara, and A. Miyajima. 1996. Mouse oncostatinM: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway. EMBO J. 15: 1055-1063.
T. Hara, K. B. Bacon, L. C. Cho, A. Yoshimura, Y. Morikawa, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, T. J. Schall, and A. Miyajima. 1995. Molecular cloning and functional characterization of a novel member of the C-C chemokine family. J. Immunol. 155: 5352-5358.
A. Yoshimura, T. Ohkubo, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, T. Hara, and A. Miyajima. 1995. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin-3 and erythropoietin receptors. EMBO J. 14: 2816-2826.
T. Hara, M. Ichihara, M. Takagi, and A. Miyajima. 1995. Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. Blood 85: 2331-2336.
J. Hannemann, T. Hara, M. Kawai, A. Miyajima, W. Ostertag, and C. Stocking. 1995. Sequential mutations in the interleukin-3(IL-3) /granulocyte-macrophage colony-stimulating factor/IL-5 receptor beta-subunit genes are necessary for the complete conversion to growth autonomy mediated by a truncated bc subunit. Mol. Cell Biol. 15: 2402-2412.
*M. Ichihara, *T. Hara, M. Takagi, L. C. Cho, D. M. Gorman, and A. Miyajima. 1995. Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. EMBO J. 14: 939-950. *First two authors equally contributed to the work.
M. Takagi, T. Hara, M. Ichihara, K. Takatsu, and A. Miyajima. 1995. Multi-colony stimulating activity of interleukin-5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively. J. Exp. Med. 181: 889-899.
I. Miyajima, L. Levitt, T. Hara, M. A. Bedell, N. G. Copeland, N.A. Jenkins, and A. Miyajima. 1995. The murine interleukin-3 receptor alpha subunit gene: chromosomal localization, genomic structure, and promoter function. Blood 85: 1246-1253.
T. Hara, N. Harada, H. Mitsui, T. Miura, T. Ishizaka, and A. Miyajima. 1994. Characterization of cell phenotype by a novel library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. Blood 84: 189-199.
T. Hara and A. Miyajima. 1994. Regulation of IL-3 receptor expression: evidence for a posttranscriptional mechanism that dominantly suppresses the expression of beta subunits. Int. Immunol. 6: 1525-1533.
T. Hara and A. Miyajima. 1994. The IL-3, GM-CSF, IL-5 receptor family. in Hematopoietic growth factors in clinical applications, 2nd ed: Mertelsmann/Herrmann., Marcel Dekker, Inc., New York. p1-17
T. Hara, M. Yamauchi, E. Takahashi, M. Hoshino, K. Aoki, D. Ayusawa, and M. Kawakita. 1993. The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus. Somat. Cell Mol. Genet. 19: 571-575.
A. Miyajima, T. Hara, and T. Kitamura. 1992. Common subunits of cytokine receptors and the functional redundancy of cytokines. TIBS 17: 378-382
T. Hara and A. Miyajima. 1992. Two distinct high affinity receptors for mouse interleukin-3 (IL-3). EMBO J. 11: 1875-1884.
T. Ogorochi, T. Hara, H.-M. Wang, K. Maruyama, and A. Miyajima. 1992. Monoclonal antibodies specific for low-affinity interleukin-3 (IL-3) binding protein AIC2A: evidence that AIC2A is a component of a high-affinity IL-3 receptor. Blood 79: 895-903.
T. Taki, K. Ogura, C. Rokukawa, T. Hara, M. Kawakita, T. Endo, A. Kobata, and S. Handa 1991. Had-1, a uridine 5'-diphosphogalactose transport-defective mutant of mouse mammary tumor cell FM3A: composition of glycolipids, cell growth inhibition by lactosylceramide, and loss of tumorigenicity. Cancer Res. 51: 1701-1707.
T. Hara, T. Endo, K. Furukawa, M. Kawakita, and A. Kobata. 1989. Elucidation of the phenotypic change on the surface of Had-1 cell, a mutant cell line of mouse FM3A carcinoma cells selected by resistance to Newcastle disease virus infection. J. Biochem. 106: 236-247.
T. Hara, S. Hattori, and M. Kawakita. 1989. Isolation and characterization of mouse FM3A cell mutants which are devoid of Newcastle disease virus receptors. J. Virol. 63: 182-188.
