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論文
- タイトル
- タイトル（英）
- [Prion-like Propagation of Pathological α-Synuclein in Vivo].
- 参照URL
- https://researchmap.jp/masamisuzukake/published_papers/35902448
- 著者
- 著者（英）
- Masami Masuda-Suzukake,Masato Hasegawa
- 担当区分
- 概要
- 概要（英）
- α-Synuclein (αS) is the major component of the filamentous inclusions that constitute the defining characteristic of neurodegenerative synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. αS is deposited in a hyperphosphorylated and ubiquitinated form with a β-sheet-rich fibrillar structure in diseased brains. In 2008, some researchers reported that embryonic neurons transplanted into Parkinson's disease brains had Lewy body-like pathologies, suggesting that pathological αS propagates from diseased neurons to young neurons. Subsequently, a growing body of evidence supported the cell-to-cell spread of αS pathologies. Recent studies have revealed that intracerebral injection of insoluble αS into wild-type mice can induce prion-like propagation of phosphorylated αS pathology even 1 month after injection, while injection into αS-knockout mice failed to induce any pathology. We also showed that intracerebral injection of insoluble αS into adult common marmoset brains results in the spreading of abundant αS pathology. These in vivo experiments clearly indicate that insoluble αS has prion-like properties and that it propagates through neural networks. The underlying mechanisms of αS propagation are still poorly understood, but αS propagation model animals could be helpful in elucidating the pathogenetic mechanisms and developing drugs for synucleinopathies.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
- 巻
- 139
- 号
- 7
- 開始ページ
- 1007
- 終了ページ
- 1013
- 出版年月
- 2019年
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1248/yakushi.18-00165-4
- 共同研究・競争的資金等の研究課題
研究者
Hasegawa Masato
( )
,
鈴掛 雅美
(スズカケ マサミ)