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論文
- タイトル
- タイトル（英）
- Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice
- 参照URL
- https://researchmap.jp/kazutakaikeda/published_papers/36330790
- 著者
- 著者（英）
- Dae Hee Han,Ilgang Hong,Ja Eun Choi,Pojeong Park,Jun-Yeong Baek,HyoJin Park,Soichiro Ide,Masayoshi Mishina,Kazutaka Ikeda,Bong-Kiun Kaang
- 担当区分
- 概要
- 概要（英）
- <title>Abstract</title>Ketamine, a non-competitive antagonist of the <italic>N</italic>-methyl-<sc>d</sc>-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts psychomimetic effects, yet demands a further investigation of its mechanism. Previous research showed that ketamine did no longer promote hyperlocomotion in GluN2D knockout (KO) mice, which is a subunit of NMDAR. In the present study, we tested whether GluN2D-containing NMDARs participate in the physiological changes in the medial prefrontal cortex (mPFC) triggered by ketamine. Sub-anesthetic dose of ketamine (25 mg/kg) elevated the frequency of spontaneous excitatory postsynaptic currents (sEPSC) in wild-type (WT) mice, but not in GluN2D KO mice, 1 h after the injection. The amplitude of sEPSC and paired-pulse ratio (PPR) were unaltered by ketamine in both WT and GluN2D KO mice. These findings suggest that GluN2D-containing NMDARs might play a role in the ketamine-mediated changes in glutamatergic neurons in mPFC and, presumably, in ketamine-induced hyperlocomotion.
- 出版者・発行元
- 出版者・発行元（英）
- Springer Science and Business Media LLC
- 誌名
- 誌名（英）
- Molecular Brain
- 巻
- 14
- 号
- 1
- 開始ページ
- 174
- 終了ページ
- 174
- 出版年月
- 2021年12月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1186/s13041-021-00883-7
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