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論文
- タイトル
- タイトル（英）
- Virus-infection in cochlear supporting cells induces audiosensory receptor hair cell death by TRAIL-induced necroptosis
- 参照URL
- https://researchmap.jp/koike-st/published_papers/38826378
- 著者
- 著者（英）
- Yushi Hayashi,Hidenori Suzuki,Wataru Nakajima,Ikuno Uehara,Atsuko Tanimura,Toshiki Himeda,Satoshi Koike,Tatsuya Katsuno,Shin-ichiro Kitajiri,Naoto Koyanagi,Yasushi Kawaguchi,Koji Onomoto,Hiroki Kato,Mitsutoshi Yoneyama,Takashi Fujita,Nobuyuki Tanaka
- 担当区分
- 概要
- 概要（英）
- Although sensorineural hearing loss (SHL) is relatively common, its cause has not been identified in most cases. Previous studies have suggested that viral infection is a major cause of SHL, especially sudden SHL, but the system that protects against pathogens in the inner ear, which is isolated by the blood-labyrinthine barrier, remains poorly understood. We recently showed that, as audiosensory receptor cells, cochlear hair cells (HCs) are protected by surrounding accessory supporting cells (SCs) and greater epithelial ridge (GER or Kölliker’s organ) cells (GERCs) against viral infections. Here, we found that virus-infected SCs and GERCs induce HC death via production of the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). Notably, the HCs expressed the TRAIL death receptors (DR) DR4 and DR5, and virus-induced HC death was suppressed by TRAIL-neutralizing antibodies. TRAIL-induced HC death was not caused by apoptosis, and was inhibited by necroptosis inhibitors. Moreover, corticosteroids, the only effective drug for SHL, inhibited the virus-induced transformation of SCs and GERCs into macrophage-like cells and HC death, while macrophage depletion also inhibited virus-induced HC death. These results reveal a novel mechanism underlying virus-induced HC death in the cochlear sensory epithelium and suggest a possible target for preventing virus-induced SHL.
- 出版者・発行元
- 出版者・発行元（英）
- Public Library of Science (PLoS)
- 誌名
- 誌名（英）
- PLOS ONE
- 巻
- 16
- 号
- 11
- 開始ページ
- e0260443
- 終了ページ
- e0260443
- 出版年月
- 2021年11月29日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1371/journal.pone.0260443
- 共同研究・競争的資金等の研究課題
研究者
小池 智
(コイケ サトシ)