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論文
- タイトル
- タイトル（英）
- Glucagon-Like Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating Remedies.
- 参照URL
- https://researchmap.jp/351K/published_papers/39616974
- 著者
- 著者（英）
- Kazunori Sango,Shizuka Takaku,Masami Tsukamoto,Naoko Niimi,Hideji Yako
- 担当区分
- 概要
- 概要（英）
- Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were developed as insulinotropic and anti-hyperglycemic agents for the treatment of type 2 diabetes, but their neurotrophic and neuroprotective activities have been receiving increasing attention. Myelin plays a key role in the functional maintenance of the central and peripheral nervous systems, and recent in vivo and in vitro studies have shed light on the beneficial effects of GLP-1RAs on the formation and protection of myelin. In this article, we describe the potential efficacy of GLP-1RAs for the induction of axonal regeneration and remyelination following nerve lesions and the prevention and alleviation of demyelinating disorders, particularly multiple sclerosis.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Frontiers in cell and developmental biology
- 巻
- 10
- 号
- 開始ページ
- 950623
- 終了ページ
- 950623
- 出版年月
- 2022年
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3389/fcell.2022.950623
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