※ をクリックすると外部の論文のサイトが開きます。
論文
- タイトル
- タイトル（英）
- [Role of Structural Polymorphisms of Tau Filaments in the Pathological Diversity of Tauopathies].
- 参照URL
- https://researchmap.jp/masatohasegawa/published_papers/43242537
- 著者
- 著者（英）
- Airi Tarutani,Masato Hasegawa
- 担当区分
- 概要
- 概要（英）
- Pathological tau protein accumulated in the brain of patients with tauopathies undergoes structural changes into amyloid-like filaments and forms the intracellular deposits that characterize the disease. Structural and biochemical classification of pathogenic tau extracted from patients' brains supports the hypothesis that structural polymorphisms of tau filaments occur in the brain. Additionally, disease-specific tau pathologies are recapitulated in in vitro and in vivo experimental models that mimic tau aggregation and dissemination and indicate that conformation of tau filaments is a key contributor to the pathological diversity in tauopathy. In this review, we describe the structural and biochemical features of pathological tau extracted from the brain of patients with tauopathies and discuss the possible mechanisms underlying amplification and dissemination of pathological tau in the brain.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Brain and nerve = Shinkei kenkyu no shinpo
- 巻
- 74
- 号
- 7
- 開始ページ
- 919
- 終了ページ
- 925
- 出版年月
- 2022年7月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.11477/mf.1416202150
- 共同研究・競争的資金等の研究課題
研究者
Hasegawa Masato
( )
,
樽谷 愛理
( )