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論文
- タイトル
- タイトル（英）
- TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens
- 参照URL
- https://researchmap.jp/read0134472/published_papers/34500833
- 著者
- 著者（英）
- Rikio Yabe,Soo-Hyun Chung,Masanori A. Murayama,Sachiko Kubo,Kenji Shimizu,Yukiko Akahori,Takumi Maruhashi,Akimasa Seno,Tomonori Kaifu,Shinobu Saijo,Yoichiro Iwakura
- 担当区分
- 筆頭著者
- 概要
- 概要（英）
- <title>Abstract</title>TARM1 is a member of the leukocyte immunoglobulin-like receptor family and stimulates macrophages and neutrophils in vitro by associating with FcRγ. However, the function of this molecule in the regulation of the immune system is unclear. Here, we show that <italic>Tarm1</italic> expression is elevated in the joints of rheumatoid arthritis mouse models, and the development of collagen-induced arthritis (CIA) is suppressed in <italic>Tarm1</italic><sup>–/–</sup> mice. T cell priming against type 2 collagen is suppressed in <italic>Tarm1</italic><sup>–/–</sup> mice and antigen-presenting ability of GM-CSF-induced dendritic cells (GM-DCs) from <italic>Tarm1</italic><sup>–/–</sup> mouse bone marrow cells is impaired. We show that type 2 collagen is a functional ligand for TARM1 on GM-DCs and promotes DC maturation. Furthermore, soluble TARM1-Fc and TARM1-Flag inhibit DC maturation and administration of TARM1-Fc blocks the progression of CIA in mice. These results indicate that TARM1 is an important stimulating factor of dendritic cell maturation and could be a good target for the treatment of autoimmune diseases.
- 出版者・発行元
- 出版者・発行元（英）
- Springer Science and Business Media LLC
- 誌名
- 誌名（英）
- Nature Communications
- 巻
- 12
- 号
- 1
- 開始ページ
- 終了ページ
- 出版年月
- 2021年12月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1038/s41467-020-20307-9
- 共同研究・競争的資金等の研究課題
研究者
矢部 力朗
(ヤベ リキオ)