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論文
- タイトル
- タイトル（英）
- Brain lipid hydroperoxide level increases in senescence-accelerated mice at an early age.
- 参照URL
- https://researchmap.jp/read0088287/published_papers/46131432
- 著者
- 著者（英）
- Fumihiko Yasui,Masaru Ishibashi,Seiichi Matsugo,Shosuke Kojo,Yutaka Oomura,Kazuo Sasaki
- 担当区分
- 概要
- 概要（英）
- We previously reported that the levels of lipid hydroperoxides, one of oxidative stress markers, in the brain and peripheral organs such as liver, heart, and lung are significantly higher in senescence accelerated-prone 8 mice (SAMP8) than in their controls, senescence accelerated-resistant mice (SAMR1), at 3, 6, and/or 9 months of age. To ascertain the exact age at which the lipid hydroperoxide levels increase in SAMP8, we measured them in the brain and liver of SAMP8 and SAMR1 at both 1 and 2 months of age. At 1 month of age, there was no significant inter-strain difference in the levels in brain or liver. However, in SAMP8 both levels were significantly greater at 2 months of age than at 1 month of age, but no such difference was detected for SAMR1. The present results suggest that SAMP8 are exposed to elevated levels of oxidative stress from an early age (2 months old), and that this may be a cause of the senescence-related impairments and degeneration in the brain and peripheral tissues (such as liver, heart, and lung) seen in this strain.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Neuroscience letters
- 巻
- 350
- 号
- 1
- 開始ページ
- 66
- 終了ページ
- 8
- 出版年月
- 2003年10月16日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0304-3940
- DOI URL
- 共同研究・競争的資金等の研究課題
研究者
安井 文彦
(ヤスイ フミヒコ)