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論文
- タイトル
- タイトル（英）
- Paediatric antibody prevalence in seizure score to predict autoimmune aetiology in seizure disorders
- 参照URL
- https://researchmap.jp/childbrain/published_papers/46291517
- 著者
- 著者（英）
- Takayuki Mori,Shimpei Matsuda,Hiroya Nishida,Kuniko Kohyama,Mitsumasa Fukuda,Hiroshi Sakuma
- 担当区分
- 概要
- 概要（英）
- AIM: To modify the antibody prevalence in epilepsy (APE) score of children with suspected autoimmune central nervous system disease with seizures. METHODS: We retrospectively analysed the cerebrospinal fluid of 157 children (aged 0-18 years) with suspected autoimmune central nervous system disease for antineuronal antibodies in our laboratory from 2016 to 2023. Participants were randomly divided into the development cohort (n = 79, 35 females; median 7 years, SD 4 years 7 months, range 4-11 years) and validation cohort (n = 78, 28 females; median 7 years, SD 4 years 5 months, range 4-12 years). A paediatric antibody prevalence in seizure (PAPS) score was created for one cohort and evaluated in the other. Seven variables were selected through univariate and multivariate analysis to create a PAPS score. RESULTS: One hundred and fifty-seven children who fulfilled the inclusion criteria were enrolled; 49 tested positive for antineuronal antibodies. The sensitivity and specificity of an APE score of 4 and greater were 92% and 22.2% respectively; the sensitivity and specificity of a PAPS score of 2.5 and greater were 83.3% and 77.8% respectively. The area under the curve was 0.832 (95% confidence interval = 0.743-0.921), which was significantly better than that for the APE score (p < 0.001). INTERPRETATION: The APE score had high sensitivity but low specificity in children. The PAPS score may be useful for determining the need for antineuronal antibody testing.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Developmental Medicine & Child Neurology
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年4月19日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1111/dmcn.15927
- 共同研究・競争的資金等の研究課題
研究者
佐久間 啓
(サクマ ヒロシ)