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論文
- タイトル
- タイトル（英）
- Macronutrient intake is associated with intelligence and neural development in adolescents
- 参照URL
- https://researchmap.jp/read0145056/published_papers/46230865
- 著者
- 著者（英）
- Yuko Nakamura,Syudo Yamasaki,Naohiro Okada,Shuntaro Ando,Atsushi Nishida,Kiyoto Kasai,Shinsuke Koike
- 担当区分
- 概要
- 概要（英）
- Introduction Macronutrient intake can be one of the most influential factors in cognitive and neural development in adolescents. Adolescence is a specific period of cognitive and neural development, and nutritional effects during this period could be life-long. Therefore, understanding the effects of macronutrient intake on cognitive and neural development in adolescents is crucially important. We thus examined the association across macronutrient intake, intelligence, and neural development using population-based cohort data. Methods We conducted two studies. In study 1, we included a total of 1,734 participants (boys, 907, age [mean ± standard deviation] 171.9 ± 3.44 months; range 163.0–186.0 months) from the Tokyo TEEN Cohort (TTC) to examine the association between macronutrient intake and intelligence quotient (IQ). In study 2, we included a total of 63 participants (boys, 38, age 174.4 ± 7.7 months; range 160.7–191.6 months) to investigate the effect of nutrition intake on neural development using graph theory analysis for resting-state functional magnetic resonance imaging (rs-fMRI) derived from a subset of the TTC. Results TTC data revealed that a higher IQ was associated in boys with increased protein intake (β = 0.068, p = 0.031), and in girls, with reduced carbohydrate intake (β = −0.076, p = 0.024). Graph theory analysis for rs-fMRI at approximately age 12 has shown that impaired local efficiency in the left inferior frontal gyrus was associated with higher carbohydrate and fat intake ([x, y, z] = [−51, 23, 8], p<sub>FDR-corrected</sub> = 0.00018 and 0.02290, respectively), whereas increased betweenness centrality in the left middle temporal gyrus was associated with higher carbohydrate, fat, and protein intake ([x, y, z] = [−61, −43, −13], p<sub>FDR-corrected</sub> = 0.0027, 0.0029, and 0.00075, respectively). Moreover, we identified a significant moderating effect of fat and protein intake on the relationship between change in betweenness centrality over a 2-year measurement gap in the left middle temporal gyrus and intelligence (β = 12.41, p = 0.0457; β = 12.12, p = 0.0401, respectively). Conclusion Our study showed the association between macronutrient intake and neural development related to intelligence in early adolescents. Appropriate nutritional intake would be a key factor for healthy cognitive and neural development.
- 出版者・発行元
- 出版者・発行元（英）
- Frontiers Media SA
- 誌名
- 誌名（英）
- Frontiers in Nutrition
- 巻
- 11
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年4月18日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3389/fnut.2024.1349738
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