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論文
- タイトル
- タイトル（英）
- Sustaining microglial reparative function enhances stroke recovery
- 参照URL
- https://researchmap.jp/junt/published_papers/46504429
- 著者
- 著者（英）
- Jun Tsuyama,Seiichiro Sakai,Kumiko Kurabayashi,Ryuki Koyama,Yuichiro Hara,Ito Kawakami,Hideya Kawaji,Takashi Shichita
- 担当区分
- 概要
- 概要（英）
- Abstract Neurological symptoms after brain injury can remain as lifelong detrimental sequelae since most spontaneous brain recovery disappears within a few months after brain injury. Microglia play an essential role in recovery processes after brain injury; however, cellular and molecular mechanisms that diminish spontaneous brain functional recovery remain unknown. We discovered by cellular fate analysis that reparative myeloid cells remained in the post-stroke brain even after losing their reparative function. ZFP384 was identified as a pivotal transcriptional regulator that diminished recovery phase–associated gene expression in reparative myeloid cells, turning them into ruined cells which lost reparative functions. ZFP384 diminished the YY1-mediated chromatin interaction necessary for expressing recovery phase–associated genes. Antisense oligonucleotide againstZfp384sustained the broad range of neural repair effects of myeloid cells and enhanced stroke recovery, even in the chronic phase of ischemic stroke recovery. Thus, therapeutics preventing the myeloid reparative immunity from reaching a ruined state sustains brain functional recovery.
- 出版者・発行元
- 出版者・発行元（英）
- Cold Spring Harbor Laboratory
- 誌名
- 誌名（英）
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年4月13日
- 査読の有無
- 招待の有無
- 掲載種別
- ISSN
- DOI URL
- https://doi.org/10.1101/2024.04.10.588813
- 共同研究・競争的資金等の研究課題