※ をクリックすると外部の論文のサイトが開きます。
論文
- タイトル
- タイトル（英）
- Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function
- 参照URL
- https://researchmap.jp/thirabay/published_papers/46360374
- 著者
- 著者（英）
- Hitomi Karyu,Takahiro Niki,Yuriko Sorimachi,Shoji Hata,Shiho Shimabukuro-Demoto,Tetsuya Hirabayashi,Kojiro Mukai,Kohji Kasahara,Keiyo Takubo,Nobuhito Goda,Koichi Honke,Tomohiko Taguchi,Hiroyuki Sorimachi,Noriko Toyama-Sorimachi
- 担当区分
- 概要
- 概要（英）
- Inhibitory natural killer (NK) cell receptors recognize MHC class I (MHC-I) in trans on target cells and suppress cytotoxicity. Some NK cell receptors recognize MHC-I in cis, but the role of this interaction is uncertain. Ly49Q, an atypical Ly49 receptor expressed in non-NK cells, binds MHC-I in cis and mediates chemotaxis of neutrophils and type I interferon production by plasmacytoid dendritic cells. We identified a lipid-binding motif in the juxtamembrane region of Ly49Q and found that Ly49Q organized functional membrane domains comprising sphingolipids via sulfatide binding. Ly49Q recruited actin-remodeling molecules to an immunoreceptor tyrosine-based inhibitory motif, which enabled the sphingolipid-enriched membrane domain to mediate complicated actin remodeling at the lamellipodia and phagosome membranes during phagocytosis. Thus, Ly49Q facilitates integrative regulation of proteins and lipid species to construct a cell type-specific membrane platform. Other Ly49 members possess lipid binding motifs; therefore, membrane platform organization may be a primary role of some NK cell receptors.
- 出版者・発行元
- 出版者・発行元（英）
- Frontiers Media SA
- 誌名
- 誌名（英）
- Frontiers in Immunology
- 巻
- 15
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年4月24日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3389/fimmu.2024.1401294
- 共同研究・競争的資金等の研究課題