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論文
- タイトル
- タイトル（英）
- ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.
- 参照URL
- https://researchmap.jp/chiakimaruyama/published_papers/46950639
- 著者
- 著者（英）
- Noe Kaneko,Kumiko Hirai,Minori Oshima,Kei Yura,Mitsuharu Hattori,Nobuaki Maeda,Chiaki Ohtaka-Maruyama
- 担当区分
- 概要
- 概要（英）
- The mammalian neocortex is formed by sequential radial migration of newborn excitatory neurons. Migrating neurons undergo a multipolar-to-bipolar transition at the subplate (SP) layer, where extracellular matrix (ECM) components are abundantly expressed. Here, we investigate the role of the ECM at the SP layer. We show that TGF-β signaling-related ECM proteins, and their downstream effector, p-smad2/3, are selectively expressed in the SP layer. We also find that migrating neurons express a disintegrin and metalloproteinase with thrombospondin motif 2 (ADAMTS2), an ECM metalloproteinase, just below the SP layer. Knockdown and knockout of Adamts2 suppresses the multipolar-to-bipolar transition of migrating neurons and disturbs radial migration. Time-lapse luminescence imaging of TGF-β signaling indicates that ADAMTS2 activates this signaling pathway in migrating neurons during the multipolar-to-bipolar transition at the SP layer. Overexpression of TGF-β2 in migrating neurons partially rescues migration defects in ADAMTS2 knockout mice. Our data suggest that ADAMTS2 secreted by the migrating multipolar neurons activates TGF-β signaling by ECM remodeling of the SP layer, which might drive the multipolar to bipolar transition.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- EMBO reports
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年6月13日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1038/s44319-024-00174-x
- 共同研究・競争的資金等の研究課題
研究者
丸山 千秋
(マルヤマ チアキ)