※ をクリックすると外部の論文のサイトが開きます。
論文
- タイトル
- タイトル（英）
- An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases.
- 参照URL
- https://researchmap.jp/hkawaji/published_papers/47204286
- 著者
- 著者（英）
- Akiko Oguchi,Akari Suzuki,Shuichiro Komatsu,Hiroyuki Yoshitomi,Shruti Bhagat,Raku Son,Raoul Jean Pierre Bonnal,Shohei Kojima,Masaru Koido,Kazuhiro Takeuchi,Keiko Myouzen,Gyo Inoue,Tomoya Hirai,Hiromi Sano,Yujiro Takegami,Ai Kanemaru,Itaru Yamaguchi,Yuki Ishikawa,Nao Tanaka,Shigeki Hirabayashi,Riyo Konishi,Sho Sekito,Takahiro Inoue,Juha Kere,Shunichi Takeda,Akifumi Takaori-Kondo,Itaru Endo,Shinpei Kawaoka,Hideya Kawaji,Kazuyoshi Ishigaki,Hideki Ueno,Yoshihide Hayashizaki,Massimiliano Pagani,Piero Carninci,Motoko Yanagita,Nicholas Parrish,Chikashi Terao,Kazuhiko Yamamoto,Yasuhiro Murakawa
- 担当区分
- 概要
- 概要（英）
- Transcribed enhancer maps can reveal nuclear interactions underpinning each cell type and connect specific cell types to diseases. Using a 5' single-cell RNA sequencing approach, we defined transcription start sites of enhancer RNAs and other classes of coding and noncoding RNAs in human CD4+ T cells, revealing cellular heterogeneity and differentiation trajectories. Integration of these datasets with single-cell chromatin profiles showed that active enhancers with bidirectional RNA transcription are highly cell type-specific and that disease heritability is strongly enriched in these enhancers. The resulting cell type-resolved multimodal atlas of bidirectionally transcribed enhancers, which we linked with promoters using fine-scale chromatin contact maps, enabled us to systematically interpret genetic variants associated with a range of immune-mediated diseases.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Science (New York, N.Y.)
- 巻
- 385
- 号
- 6704
- 開始ページ
- eadd8394
- 終了ページ
- 出版年月
- 2024年7月5日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1126/science.add8394
- 共同研究・競争的資金等の研究課題
研究者
川路 英哉
( )