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論文
- タイトル
- タイトル（英）
- An osteoinductive surface by adhesive bone morphogenetic protein-2 prepared using the bioorthogonal approach for tight binding of titanium with bone.
- 参照URL
- https://researchmap.jp/tsujihiro/published_papers/47379404
- 著者
- 著者（英）
- Xueli Ren,Hironori Tsuji,Takahiko Uchino,Izumi Kono,Takashi Isoshima,Akimitsu Okamoto,Noriyuki Nagaoka,Toshifumi Ozaki,Akihiro Matsukawa,Hideyuki Miyatake,Yoshihiro Ito
- 担当区分
- 概要
- 概要（英）
- Inorganic biomaterials are used in various orthopedic and dental implants. Nevertheless, they cause clinical issues such as loosening of implants and patient morbidity. Therefore, inspired by mussel adhesive proteins, we aimed to design an adhesive and dimer-forming highly active bone morphogenetic protein-2 (BMP-2) using bioorthogonal chemistry, in which recombinant DNA technology was combined with enzymatic modifications, to achieve long-term osseointegration with titanium. The prepared BMP-2 exhibited substantially higher binding activity than wild-type BMP-2, while the adhered BMP-2 was more active than soluble BMP-2. Therefore, the adhesive BMP-2 was immobilized onto titanium wires and screws and implanted into rat bones, and long-term osteogenesis was evaluated. Adhesive BMP-2 promoted the mechanical binding of titanium to bones, enabling efficient bone regeneration and effective stabilization of implants. Thus, such adhesive biosignaling proteins can be used in regenerative medicine.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Journal of materials chemistry. B
- 巻
- 12
- 号
- 12
- 開始ページ
- 3006
- 終了ページ
- 3014
- 出版年月
- 2024年3月20日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1039/d3tb02838k
- 共同研究・競争的資金等の研究課題
研究者
辻 寛謙
( )