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論文
- タイトル
- タイトル（英）
- TMEM132C rs7296262 Single-Nucleotide Polymorphism Is Significantly Associated with Nausea Induced by Opioids Administered for Cancer Pain and Postoperative Pain
- 参照URL
- https://researchmap.jp/kazutakaikeda/published_papers/47415919
- 著者
- 著者（英）
- Yuna Kang,Daisuke Nishizawa,Seii Ohka,Takeshi Terui,Kunihiko Ishitani,Ryozo Morino,Miyuki Yokota,Junko Hasegawa,Kyoko Nakayama,Yuko Ebata,Kyotaro Koshika,Tatsuya Ichinohe,Kazutaka Ikeda
- 担当区分
- 概要
- 概要（英）
- Opioids are almost mandatorily used for analgesia for cancer pain and postoperative pain. Opioid analgesics commonly induce nausea as a side effect. However, the genetic factors involved are still mostly unknown. To clarify the genetic background of individual differences in the occurrence of nausea during opioid administration, the incidence of nausea was investigated in 331 patients (Higashi-Sapporo Hospital [HS] group) who received morphine chronically for cancer pain treatment and in 2021 patients (Cancer Institute Hospital [CIH] group) who underwent elective surgery under general anesthesia. We conducted a genome-wide association study of nausea in HS samples. Among the top 20 candidate single-nucleotide polymorphisms (SNPs), we focused on the TMEM132C rs7296262 SNP, which has been reportedly associated with psychiatric disorders. The rs7296262 SNP was significantly associated with nausea in both the HS and CIH groups (TT+TC vs. CC; HS group, p = 0.0001; CIH group, p = 0.0064). The distribution of nausea-prone genotypes for the rs7296262 SNP was reversed between HS and CIH groups. These results suggest that the TMEM132C rs7296262 SNP is significantly associated with nausea during opioid use, and the effect of the SNP genotype on nausea is reversed between chronic and acute phases of opioid use.
- 出版者・発行元
- 出版者・発行元（英）
- MDPI AG
- 誌名
- 誌名（英）
- International Journal of Molecular Sciences
- 巻
- 25
- 号
- 16
- 開始ページ
- 8845
- 終了ページ
- 8845
- 出版年月
- 2024年8月14日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3390/ijms25168845
- 共同研究・競争的資金等の研究課題