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論文
- タイトル
- タイトル（英）
- Ubiquitin‐mediated endosomal stress: A novel organelle stress of early endosomes that initiates cellular signaling pathways
- 参照URL
- https://researchmap.jp/read0000903/published_papers/47966856
- 著者
- 著者（英）
- Akinori Endo,Masayuki Komada,Yukiko Yoshida
- 担当区分
- 概要
- 概要（英）
- Abstract Cells utilize diverse organelles to maintain homeostasis and to respond to extracellular stimuli. Recently, multifaceted aspects of organelle stress caused by various factors have been emerging. The endosome is an essential organelle, functioning as the central hub for membrane trafficking in cooperation with the ubiquitin system. However, knowledge regarding endosomal stress, which refers to organelle stress of the endosome, is currently limited. We recently revealed ubiquitin‐mediated endosomal stress of early endosomes (EEs) and its responsive signaling pathways. These findings shed light on the relevance of ubiquitin‐mediated endosomal stress to physiological and pathological processes. Here, we present a hypothesis that ubiquitin‐mediated endosomal stress may have significant roles in biological contexts and that ubiquitin‐specific protease 8 is a key regulator of ubiquitin clearance from EEs.
- 出版者・発行元
- 出版者・発行元（英）
- Wiley
- 誌名
- 誌名（英）
- BioEssays
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年8月28日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0265-9247
- DOI URL
- https://doi.org/10.1002/bies.202400127
- 共同研究・競争的資金等の研究課題