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論文
- タイトル
- タイトル（英）
- Prefrontal synaptic regulation of homeostatic sleep pressure revealed through synaptic chemogenetics.
- 参照URL
- https://researchmap.jp/n_kurabayashi/published_papers/48011770
- 著者
- 著者（英）
- Takeshi Sawada,Yusuke Iino,Kensuke Yoshida,Hitoshi Okazaki,Shinnosuke Nomura,Chika Shimizu,Tomoki Arima,Motoki Juichi,Siqi Zhou,Nobuhiro Kurabayashi,Takeshi Sakurai,Sho Yagishita,Masashi Yanagisawa,Taro Toyoizumi,Haruo Kasai,Shoi Shi
- 担当区分
- 概要
- 概要（英）
- Sleep is regulated by homeostatic processes, yet the biological basis of sleep pressure that accumulates during wakefulness, triggers sleep, and dissipates during sleep remains elusive. We explored a causal relationship between cellular synaptic strength and electroencephalography delta power indicating macro-level sleep pressure by developing a theoretical framework and a molecular tool to manipulate synaptic strength. The mathematical model predicted that increased synaptic strength promotes the neuronal "down state" and raises the delta power. Our molecular tool (synapse-targeted chemically induced translocation of Kalirin-7, SYNCit-K), which induces dendritic spine enlargement and synaptic potentiation through chemically induced translocation of protein Kalirin-7, demonstrated that synaptic potentiation of excitatory neurons in the prefrontal cortex (PFC) increases nonrapid eye movement sleep amounts and delta power. Thus, synaptic strength of PFC excitatory neurons dictates sleep pressure in mammals.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Science (New York, N.Y.)
- 巻
- 385
- 号
- 6716
- 開始ページ
- 1459
- 終了ページ
- 1465
- 出版年月
- 2024年9月27日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1126/science.adl3043
- 共同研究・競争的資金等の研究課題
研究者
倉林 伸博
(クラバヤシ ノブヒロ)