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論文
- タイトル
- タイトル（英）
- Loss of a single Zn finger, but not that of two Zn fingers, of GATA3 drives skin inflammation.
- 参照URL
- https://researchmap.jp/Igutomo/published_papers/48404694
- 著者
- 著者（英）
- Tomohiro Iguchi,Makiko Toma-Hirano,Masakatsu Takanashi,Hisao Masai,Shoichiro Miyatake
- 担当区分
- 筆頭著者
- 概要
- 概要（英）
- Transcription factor GATA3 is essential for the developmental processes of T cells. Recently, the silencer of a cytokine IFNγ gene was identified, the inhibitory activity of which requires GATA3. GATA3 has 2 Zn fingers and the commonly used GATA3 deficient mice lack both fingers (D2). We have established a mouse line that lacks only one Zn finger close to the C terminus (D1). The D1 mice line developed dermatitis, which was not observed in D2 mice. The expression of S100a8/S100a9 was elevated in D1 to a level higher than in D2, suggesting their roles in dermatitis development. CD8 T cells of both D1 and D2 lines expressed inhibitory receptors associated with the exhausted state. In the absence of MHC class II, the skin inflammation was exacerbated in both lines. The gene expression pattern of CD8 T cells became similar to that of effector T cells. Blocking Ab against LAG3 upregulated the expression of the effector molecules of T cells. These results suggest that the disfunction of GATA3 can lead to the spontaneous activation of CD8 T cells that causes skin inflammation, and that suppressive activity of MHC class II - LAG3 interaction ameliorates dermatitis development.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Genes to cells : devoted to molecular & cellular mechanisms
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年10月22日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1111/gtc.13171
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