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論文
- タイトル
- タイトル（英）
- Imaging α-synuclein pathologies in animal models and patients with Parkinson’s and related diseases
- 参照URL
- https://researchmap.jp/shimozawaaki/published_papers/48561748
- 著者
- 著者（英）
- Hironobu Endo,Maiko Ono,Yuhei Takado,Kiwamu Matsuoka,Manami Takahashi,Kenji Tagai,Yuko Kataoka,Kosei Hirata,Keisuke Takahata,Chie Seki,Naomi Kokubo,Masayuki Fujinaga,Wakana Mori,Yuji Nagai,Koki Mimura,Katsushi Kumata,Tatsuya Kikuchi,Aki Shimozawa,Sushil K. Mishra,Yoshiki Yamaguchi,Hiroshi Shimizu,Akiyoshi Kakita,Hiroyuki Takuwa,Hitoshi Shinotoh,Hitoshi Shimada,Yasuyuki Kimura,Masanori Ichise,Tetsuya Suhara,Takafumi Minamimoto,Naruhiko Sahara,Kazunori Kawamura,Ming-Rong Zhang,Masato Hasegawa,Makoto Higuchi
- 担当区分
- 概要
- 概要（英）
- SUMMARY Deposition of α-synuclein fibrils is implicated in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), whilein vivodetection of α-synuclein pathologies in these illnesses has been challenging. Here, we have developed a small-molecule ligand, C05-05, for visualizing α-synuclein deposits in the brains of living subjects.In vivooptical and positron emission tomography (PET) imaging of mouse and marmoset models demonstrated that C05-05 captured a dynamic propagation of fibrillogenesis along neural pathways followed by disruptions of these structures. High-affinity binding of<sup>18</sup>F-C05-05 to α-synuclein aggregates in human brain tissues was also proven byin vitroassays. Notably, PET-detectable<sup>18</sup>F-C05-05 signals were intensified in the midbrains of PD and DLB patients as compared to healthy controls, providing the first demonstration of visualizing α-synuclein pathologies in these illnesses. Collectively, we propose a new imaging technology offering neuropathology-based translational assessments of PD and allied disorders towards diagnostic and therapeutic research and development.
- 出版者・発行元
- 出版者・発行元（英）
- Cold Spring Harbor Laboratory
- 誌名
- 誌名（英）
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2020年10月23日
- 査読の有無
- 招待の有無
- 掲載種別
- ISSN
- DOI URL
- https://doi.org/10.1101/2020.10.23.349860
- 共同研究・競争的資金等の研究課題
研究者
下沢 明希
(シモザワ アキ)