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論文
- タイトル
- タイトル（英）
- Mitochondrial quality control via organelle and protein degradation.
- 参照URL
- https://researchmap.jp/yamano_K/published_papers/49786205
- 著者
- 著者（英）
- Koji Yamano,Hiroki Kinefuchi,Waka Kojima
- 担当区分
- 概要
- 概要（英）
- Mitochondria are essential eukaryotic organelles that produce ATP as well as synthesize various macromolecules. They also participate in signalling pathways such as the innate immune response and apoptosis. These diverse functions are performed by >1,000 different mitochondrial proteins. Although mitochondria are continuously exposed to potentially damaging conditions such as reactive oxygen species, proteases/peptidases localized in different mitochondrial subcompartments, termed mitoproteases, maintain mitochondrial quality and integrity. In addition to processing incoming precursors and degrading damaged proteins, mitoproteases also regulate metabolic reactions, mitochondrial protein half-lives and gene transcription. Impaired mitoprotease function is associated with various pathologies. In this review, we highlight recent advances in our understanding of mitochondrial quality control regulated by autophagy, ubiquitin-proteasomes and mitoproteases.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Journal of biochemistry
- 巻
- 175
- 号
- 5
- 開始ページ
- 487
- 終了ページ
- 494
- 出版年月
- 2024年4月29日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1093/jb/mvad106
- 共同研究・競争的資金等の研究課題
研究者
山野 晃史
( )