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論文
- タイトル
- タイトル（英）
- Conserved interhemispheric morphogenesis in amniotes preceded the evolution of the corpus callosum
- 参照URL
- https://researchmap.jp/chiakimaruyama/published_papers/48625635
- 著者
- 著者（英）
- Ryota Noji,Mari Kaneko,Takaya Abe,Hiroshi Kiyonari,Yukihiro Nishikawa,Takuma Kumamoto,Hitoshi Gotoh,Chiaki Ohtaka-Maruyama,Katsuhiko Ono,Tatsuya Yoshizawa,Tadashi Nomura
- 担当区分
- 概要
- 概要（英）
- SUMMARY The corpus callosum (CC) is the large axon bundle connecting the telencephalic hemispheres. The CC is formed exclusively in placental mammals, and the lack of comparable structures in other amniotes obscures the evolutionary origin of the CC. We here demonstrate that interhemispheric remodeling, a prior developmental step for CC formation, is highly conserved in non-mammalian amniotes, such as reptiles and birds. In these animal groups, the spatiotemporal dynamics of interhemispheric remodeling are tightly connected with distinct commissural formations. We observed a high degree of similarity between the mammalian CC and reptilian rostral pallial commissure, (RPC) and significant modifications in the avian pallial projection. Furthermore, we determined that Satb2 plays crucial roles in interhemispheric remodeling, which is associated with proper formation of both the CC and RPC in mice and geckoes, via the use of CRISPR-mediated gene-targeting. Our findings suggest that developmental mechanisms for midline remodeling were already present in the common ancestor of amniotes, which contributed to the evolution of eutherian-specific CC formation.
- 出版者・発行元
- 出版者・発行元（英）
- Cold Spring Harbor Laboratory
- 誌名
- 誌名（英）
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年12月4日
- 査読の有無
- 招待の有無
- 掲載種別
- ISSN
- DOI URL
- https://doi.org/10.1101/2024.12.03.625459
- 共同研究・競争的資金等の研究課題
研究者
丸山 千秋
(マルヤマ チアキ)