※ をクリックすると外部の論文のサイトが開きます。
論文
- タイトル
- タイトル（英）
- Genetic prognostic markers in LymphGen-unclassifiable diffuse large B cell lymphoma.
- 参照URL
- https://researchmap.jp/obokikeisuke/published_papers/51475770
- 著者
- 著者（英）
- Yusuke Kanemasa,Daichi Sadato,Maya Isogai,Mina Ogawa,Chizuko Hirama,Hideya Kawaji,Tatsuro Yamaguchi,Yuka Harada,Tsunekazu Hishima,Keisuke Oboki,Tatsu Shimoyama
- 担当区分
- 責任著者
- 概要
- 概要（英）
- Diffuse large B cell lymphoma (DLBCL), the most common subtype of non-Hodgkin lymphoma, has variable treatment responses and distinct molecular subtypes. Despite therapeutic advances, a significant number of patients experience treatment failure or relapse. Recent genetic subtyping methods, such as the LymphGen algorithm, classify DLBCL into molecular subtypes. However, a subset of cases remains categorized as "LymphGen-unclassifiable" ("Other" group in the LymphGen classification). These cases lack distinctive genetic features and present challenges for risk assessment. In this study, we aimed to identify prognostic genetic markers specific to LymphGen-unclassifiable DLBCL. Using a discovery cohort from the National Cancer Institute, we identified genetic alterations in CDKN2A and PIM1 that were significantly associated with overall survival in this patient group. We then validated the model in a separate cohort from Komagome Hospital in Tokyo. Our model, combined with the International Prognostic Index (IPI), identified high-risk LymphGen-unclassifiable DLBCL patients within the high-risk IPI group, showing a 2-year overall survival rate of 38% versus 72%. This approach could support the development of more targeted therapies by improving prognostic accuracy and advancing understanding of LymphGen-unclassifiable DLBCL.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- International journal of hematology
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2025年9月12日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1007/s12185-025-04065-2
- 共同研究・競争的資金等の研究課題