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論文
- タイトル
- タイトル（英）
- Increased granulovacuolar degeneration in the thalamus and higher neurofibrillary tangle Braak stages in bipolar disorder.
- 参照URL
- https://researchmap.jp/Ito_K/published_papers/52798423
- 著者
- 著者（英）
- Akito Nagakura,Ito Kawakami,Araki Kimura,Kenji Ikeda,Kenichi Oshima,Mie Kubota-Sakashita,Tadafumi Kato
- 担当区分
- 概要
- 概要（英）
- AIM: Recent neuropathological studies suggest that the accumulation of neurodegenerative disease-associated proteins in subcortical structures may contribute to mood symptoms. Animal models have highlighted the role of the paraventricular thalamic nucleus (PVT) in bipolar disorder (BD) pathophysiology. However, neuropathological investigations in the thalamus in BD remain limited. This study aimed to examine neurodegenerative pathology in the thalamus and medial temporal region including the hippocampus in patients with BD. METHODS: Postmortem brain tissues of the thalamus and medial temporal region of nine patients with BD and nine age-matched controls were obtained from Matsuzawa Hospital, with additional medial temporal samples of 14 BD cases acquired from the Stanley Foundation Brain Bank. Immunohistochemical analyses were performed using antibodies against phosphorylated tau, amyloid-β, α-synuclein, TDP-43, and granulovacuolar degeneration (GVD) markers including CHMP2B and CK-1δ. RESULTS: The 23 BD cases exhibited a significantly greater burden of tau pathologies, including higher neurofibrillary tangle Braak stages (P = 0.015) and more severe argyrophilic grain Saito stage (P = 0.029), compared with the nine controls. Notably, CHMP2B-positive GVD was significantly more frequently observed in the PVT of BD cases than in the controls (five of nine vs. zero of nine, P = 0.029). CONCLUSIONS: These findings suggest that neurodegenerative processes, particularly tau pathology and CHMP2B-positive GVD in the PVT may play a role in BD pathophysiology.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Psychiatry and clinical neurosciences
- 巻
- 79
- 号
- 12
- 開始ページ
- 801
- 終了ページ
- 807
- 出版年月
- 2025年12月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1111/pcn.13891
- 共同研究・競争的資金等の研究課題
研究者
河上 緒
(カワカミ イト)