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論文
- タイトル
- タイトル（英）
- Pathogenic human autoantibodies against NMDA receptor alter dendritic spine size.
- 参照URL
- https://researchmap.jp/kasai_yamamoto_m/published_papers/52169085
- 著者
- 著者（英）
- Shimpei Matsuda,Takayuki Mori,Mariko Kasai,Kuniko Kohyama,Tadayuki Shimada,Hiroshi Sakuma
- 担当区分
- 概要
- 概要（英）
- Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis (NMDARE) is an autoimmune neurological disorder associated with anti-NMDAR antibodies (NMDAR-Ab), leading to synaptic dysfunction. While the effect of NMDAR-Ab on receptor internalization is well documented, its effect on dendritic protrusion morphology remains unclear. To investigate how NMDAR-Ab alters dendritic protrusion size and the associated molecular mechanisms using patient-derived sera. Cultured hippocampal neurons were treated with sera from patients with NMDARE. Protrusion size and the phosphorylation of cofilin, a regulator of actin dynamics, were also assessed. Exposure to NMDAR-Ab significantly decreased dendritic protrusion width and length while increasing protrusion density. Mechanistically, NMDAR-Ab decreased cofilin phosphorylation in dendritic protrusions. The reduction in spine size was partially reversible upon discontinuation of antibody treatment, except for the reduction in phosphorylated cofilin levels. NMDAR-Ab induced changes in dendritic protrusion size, along with alterations in actin dynamics, which may contribute to the cognitive and behavioral symptoms of NMDARE.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Scientific reports
- 巻
- 16
- 号
- 1
- 開始ページ
- 3851
- 終了ページ
- 3851
- 出版年月
- 2026年1月3日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1038/s41598-025-34027-x
- 共同研究・競争的資金等の研究課題