※ をクリックすると外部の論文のサイトが開きます。
論文
- タイトル
- タイトル（英）
- Neuropeptide signalling and perineurial barrier generate a persistent stress-induced internal state in<i>Drosophila</i>
- 参照URL
- https://researchmap.jp/minorusaitoe/published_papers/52408475
- 著者
- 著者（英）
- Abdalla G. Alia,Xinyue Hu,Yuzhe Gu,Guangnan Tian,Julie L. Semmelhack,Kokoro Saito,Hiromu Tanimoto,Koki Tsuyuzaki,Shintaro Naganos,Tomoyuki Miyashita,Minoru Saitoe,Yukinori Hirano
- 担当区分
- 概要
- 概要（英）
- Abstract Although fear conditioning has elucidated cue-evoked acute fear responses, the mechanisms by which stress experiences induce generalized internal states linked to anxiety are poorly understood. Here, we report that robust stress induces a persistent behavioral change characterized by avoidance of a confined space, claustrophobia-like behavior inDrosophila. Unlike aversive memory formation, the development of claustrophobia-like behavior does not require dopamine receptors. Our neuronal screening determined that neuropeptide signalling via Allatostatin-A inactivates the downstream neurons via its receptor AstA-R1, causally inducing claustrophobia-like behavior. Moreover, gene expression profiling of individual fly heads revealed that immune response activation in perineurial barrier is involved in claustrophobia-like behavior. Our data demonstrate that stress-induced persistent behavioral change would not be related to a canonical mechanism of aversive memory formation, rather involves neuropeptidergic signalling and perineurial barrier, providing the mechanism determining internal states which persistently change behavioral modes.
- 出版者・発行元
- 出版者・発行元（英）
- Cold Spring Harbor Laboratory
- 誌名
- 誌名（英）
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2025年5月13日
- 査読の有無
- 招待の有無
- 掲載種別
- ISSN
- DOI URL
- https://doi.org/10.1101/2025.05.08.652787
- 共同研究・競争的資金等の研究課題