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論文
- タイトル
- タイトル（英）
- A mouse circadian proteome atlas.
- 参照URL
- https://researchmap.jp/Yoshitane/published_papers/52802907
- 著者
- 著者（英）
- Yuta Otobe,Norie Deki-Arima,Shao Xinyan,Kazuma Itabashi,Nobuhiro Kurabayashi,Utaro Nakamura,Anna Uchida,Ryutaro Shimazaki,Kaneyoshi Yamamoto,Takeshi Sakurai,Ying-Hui Fu,Louis J Ptáček,Arisa Hirano,Masao Doi,Hikari Yoshitane
- 担当区分
- 概要
- 概要（英）
- The circadian clock drives daily rhythms of gene expression and physiology. Advances in next-generation DNA sequencing have provided extensive insights into RNA expression, but more functional information at the protein level with sufficient depth has been limited by technical challenges. In this study, we generated a comprehensive mouse circadian proteome atlas (https://chronoproteinology.org/circadian_atlas) by analyzing 32 tissues, including the suprachiasmatic nucleus (SCN), using the next-generation mass spectrometer Orbitrap Astral. Data-independent acquisition of 584 samples, including developmental samples, revealed the spatiotemporal profiles of about 19,000 proteins. Proteome and phospho-proteome analyses of whole-cell and nuclear proteins in the liver revealed circadian changes in protein quantity and quality, as well as global changes in hPER2-S662G mutant mice, a genetic model of human familial advanced sleep phase (FASP). This multi-tissue circadian proteome atlas provides a fundamental resource for understanding when, where, and which proteins are expressed and function.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Molecular cell
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2026年1月9日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1016/j.molcel.2025.12.020
- 共同研究・競争的資金等の研究課題