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論文
- タイトル
- Cognitive control affects motor learning through local variations in GABA within the primary motor cortex
- タイトル(英)
- Cognitive control affects motor learning through local variations in GABA within the primary motor cortex
- 参照URL
- https://researchmap.jp/sugashou/published_papers/33856121
- 著者
- Shuki Maruyama,Masaki Fukunaga,Sho K. Sugawara,Yuki H. Hamano,Tetsuya Yamamoto,Norihiro Sadato
- 著者(英)
- Shuki Maruyama,Masaki Fukunaga,Sho K. Sugawara,Yuki H. Hamano,Tetsuya Yamamoto,Norihiro Sadato
- 担当区分
- 概要
- 概要(英)
Abstract The primary motor cortex (M1) is crucial for motor learning; however, its interaction with other brain areas during motor learning remains unclear. We hypothesized that the fronto-parietal execution network (FPN) provides learning-related information critical for the flexible cognitive control that is required for practice. We assessed network-level changes during sequential finger tapping learning under speed pressure by combining magnetic resonance spectroscopy and task and resting-state functional magnetic resonance imaging. There was a motor learning-related increase in preparatory activity in the fronto-parietal regions, including the right M1, overlapping the FPN and sensorimotor network (SMN). Learning-related increases in M1-seeded functional connectivity with the FPN, but not the SMN, were associated with decreased GABA/glutamate ratio in the M1, which were more prominent in the parietal than the frontal region. A decrease in the GABA/glutamate ratio in the right M1 was positively correlated with improvements in task performance (p = 0.042). Our findings indicate that motor learning driven by cognitive control is associated with local variations in the GABA/glutamate ratio in the M1 that reflects remote connectivity with the FPN, representing network-level motor sequence learning formations.- 出版者・発行元
- 出版者・発行元(英)
- Springer Science and Business Media LLC
- 誌名
- Scientific Reports
- 誌名(英)
- Scientific Reports
- 巻
- 11
- 号
- 1
- 開始ページ
- 18566
- 終了ページ
- 出版年月
- 2021年12月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文(学術雑誌)
- ISSN
- DOI URL
- https://doi.org/10.1038/s41598-021-97974-1
- 共同研究・競争的資金等の研究課題
研究者
菅原 翔
(スガワラ ショウ)