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論文
タイトル
Cognitive control affects motor learning through local variations in GABA within the primary motor cortex
タイトル(英)
Cognitive control affects motor learning through local variations in GABA within the primary motor cortex
参照URL
https://researchmap.jp/sugashou/published_papers/33856121
著者
Shuki Maruyama,Masaki Fukunaga,Sho K. Sugawara,Yuki H. Hamano,Tetsuya Yamamoto,Norihiro Sadato
著者(英)
Shuki Maruyama,Masaki Fukunaga,Sho K. Sugawara,Yuki H. Hamano,Tetsuya Yamamoto,Norihiro Sadato
担当区分
概要
概要(英)
AbstractThe primary motor cortex (M1) is crucial for motor learning; however, its interaction with other brain areas during motor learning remains unclear. We hypothesized that the fronto-parietal execution network (FPN) provides learning-related information critical for the flexible cognitive control that is required for practice. We assessed network-level changes during sequential finger tapping learning under speed pressure by combining magnetic resonance spectroscopy and task and resting-state functional magnetic resonance imaging. There was a motor learning-related increase in preparatory activity in the fronto-parietal regions, including the right M1, overlapping the FPN and sensorimotor network (SMN). Learning-related increases in M1-seeded functional connectivity with the FPN, but not the SMN, were associated with decreased GABA/glutamate ratio in the M1, which were more prominent in the parietal than the frontal region. A decrease in the GABA/glutamate ratio in the right M1 was positively correlated with improvements in task performance (p = 0.042). Our findings indicate that motor learning driven by cognitive control is associated with local variations in the GABA/glutamate ratio in the M1 that reflects remote connectivity with the FPN, representing network-level motor sequence learning formations.
出版者・発行元
出版者・発行元(英)
Springer Science and Business Media LLC
誌名
Scientific Reports
誌名(英)
Scientific Reports
11
1
開始ページ
18566
終了ページ
出版年月
2021年12月
査読の有無
査読有り
招待の有無
掲載種別
研究論文(学術雑誌)
ISSN
DOI URL
https://doi.org/10.1038/s41598-021-97974-1
共同研究・競争的資金等の研究課題
研究者
菅原 翔 (スガワラ ショウ)