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論文
- タイトル
- タイトル（英）
- Malaria Parasites Hijack Host Receptors From Exosomes to Capture Lipoproteins
- 参照URL
- https://researchmap.jp/komatsuya/published_papers/35849525
- 著者
- 著者（英）
- Naoyuki Iso-o,Keisuke Komatsuya,Fuyuki Tokumasu,Noriko Isoo,Tomohiro Ishigaki,Hiroshi Yasui,Hiroshi Yotsuyanagi,Masumi Hara,Kiyoshi Kita
- 担当区分
- 概要
- 概要（英）
- Malaria parasites cannot multiply in host erythrocytes without cholesterol because they lack complete sterol biosynthesis systems. This suggests parasitized red blood cells (pRBCs) need to capture host sterols, but its mechanism remains unknown. Here we identified a novel high-density lipoprotein (HDL)-delivery pathway operating in blood-stage
Plasmodium . In parasitized mouse plasma, exosomes positive for scavenger receptor CD36 and platelet-specific CD41 increased. These CDs were detected in pRBCs and internal parasites. A low molecular antagonist for scavenger receptors, BLT-1, blocked HDL uptake to pRBCs and suppressedPlasmodium growthin vitro . Furthermore, platelet-derived exosomes were internalized in pRBCs. Thus, we presume CD36 is delivered to malaria parasites from platelets by exosomes, which enables parasites to steal HDL for cholesterol supply. Cholesterol needs to cross three membranes (RBC, parasitophorous vacuole and parasite’s plasma membranes) to reach parasite, but our findings can explain the first step of sterol uptake by intracellular parasites. - 出版者・発行元
- 出版者・発行元（英）
- Frontiers Media SA
- 誌名
- 誌名（英）
- Frontiers in Cell and Developmental Biology
- 巻
- 9
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2021年11月11日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3389/fcell.2021.749153
- 共同研究・競争的資金等の研究課題
研究者
小松谷 啓介
( )