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論文
- タイトル
- タイトル（英）
- [Animal models of synucleinopathies: prion-like propagation of alpha-synuclein in wild-type animals].
- 参照URL
- https://researchmap.jp/masamisuzukake/published_papers/35902446
- 著者
- 著者（英）
- Masami Masuda-Suzukake
- 担当区分
- 概要
- 概要（英）
- Accumulation of insoluble alpha-synuclein (αS) is a pathological hallmark of some progressive neurodegenerative diseases including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, collectively termed synucleinopathies. In diseased brain, αS forms β-sheet-rich amyloid fibrils and it is accumulated in neurons or glial cells. A growing body of evidence suggests that spreading of αS pathology occur by prion-like propagation mechanisms. Our study revealed that intracerebral injection of synthetic αS amyloid fibrils into wild-type mice induced prion-like propagation of αS pathology at 1 month post injection, while injection of soluble αS did not induce αS pathology. Furthermore, injection of αS amyloid fibrils into αS knockout mice failed to induce any pathologies. We also have demonstrated that intracerebral injection of αS amyloid fibrils into small primates, adult common marmosets, resulted in spreading of αS pathologies and loss of TH-positive neurons. These in vivo experiments clearly indicate that αS amyloid fibrils has prion-like properties and it propagates through neural networks. The underlying mechanisms of αS propagation are poorly understood, however, αS propagation model animals would be useful in elucidating pathogenetic mechanisms and developing disease-modifying drugs for sporadic synucleinopathies.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Nihon yakurigaku zasshi. Folia pharmacologica Japonica
- 巻
- 154
- 号
- 6
- 開始ページ
- 301
- 終了ページ
- 305
- 出版年月
- 2019年
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1254/fpj.154.301
- 共同研究・競争的資金等の研究課題
研究者
鈴掛 雅美
(スズカケ マサミ)