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論文
- タイトル
- タイトル（英）
- MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome".
- 参照URL
- https://researchmap.jp/toyonatsume/published_papers/36053456
- 著者
- 著者（英）
- Subhendu K Das,Vladislav Kuzin,Donald P Cameron,Suzanne Sanford,Rajiv Kumar Jha,Zuqin Nie,Marta Trullols Rosello,Ronald Holewinski,Thorkell Andresson,Jan Wisniewski,Toyoaki Natsume,David H Price,Brian A Lewis,Fedor Kouzine,David Levens,Laura Baranello
- 担当区分
- 概要
- 概要（英）
- High-intensity transcription and replication supercoil DNA to levels that can impede or halt these processes. As a potent transcription amplifier and replication accelerator, the proto-oncogene MYC must manage this interfering torsional stress. By comparing gene expression with the recruitment of topoisomerases and MYC to promoters, we surmised a direct association of MYC with topoisomerase 1 (TOP1) and TOP2 that was confirmed in vitro and in cells. Beyond recruiting topoisomerases, MYC directly stimulates their activities. We identify a MYC-nucleated "topoisome" complex that unites TOP1 and TOP2 and increases their levels and activities at promoters, gene bodies, and enhancers. Whether TOP2A or TOP2B is included in the topoisome is dictated by the presence of MYC versus MYCN, respectively. Thus, in vitro and in cells, MYC assembles tools that simplify DNA topology and promote genome function under high output conditions.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Molecular cell
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2021年12月6日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1016/j.molcel.2021.11.016
- 共同研究・競争的資金等の研究課題
研究者
夏目 豊彰
(ナツメ トヨアキ)