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論文
- タイトル
- タイトル（英）
- Substantia nigra pars reticulata mediated sleep and motor activity regulation.
- 参照URL
- https://researchmap.jp/SleepLab/published_papers/30760732
- 著者
- 著者（英）
- Yuan-Yang Lai,Tohru Kodama,Kung-Chiao Hsieh,Darian Nguyen,Jerome M Siegel
- 担当区分
- 概要
- 概要（英）
- STUDY OBJECTIVES: The substantia nigra pars reticulata (SNR) is a major output nucleus of the basal ganglia. Animal studies have shown that lesions of the SNR cause hyposomnia and motor hyperactivity, indicating that the SNR may play a role in the control of sleep and motor activity. METHODS: Eight 8-10 week old adult male Sprague-Dawley rats were used. After 3-days of baseline polysomnographic recording, dialysates were collected from the lateral SNR across natural sleep-wake states. Muscimol and bicuculline were microinfused into the lateral SNR. RESULTS: We found that GABA release in the lateral SNR is negatively correlated with slow wave sleep (SWS; R= -0.266, p<0.01, n=240) and positively correlated with waking (R=0.265, p<0.01, n=240) in rats. Microinfusion of muscimol into the lateral SNR decreased sleep time and sleep quality, as well as eliciting motor hyperactivity in wake and increased periodic leg movement (PLM) in SWS, while bicuculline infused into the lateral SNR increased sleep and decreased motor activity in SWS in rats. Muscimol infusion skewed the distribution of inter-movement intervals, with most between 10 to 20 seconds, while a flat distribution of intervals between 10 to 90 seconds was seen in baseline conditions. CONCLUSION: Activation of the lateral SNR is important for inducing sleep and inhibiting motor activity prior to and during sleep, and thus to the maintenance of sleep. Abnormal function of the lateral SNR may cause hyposomnia and motor hyperactivity in quiet wake and in sleep.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Sleep
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2020年8月18日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1093/sleep/zsaa151
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )