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論文
- タイトル
- タイトル（英）
- Novel psychoactive benzofurans strongly increase extracellular serotonin level in mouse corpus striatum
- 参照URL
- https://researchmap.jp/SleepLab/published_papers/28125178
- 著者
- 著者（英）
- Tatsu Fuwa,Jin Suzuki,Toyohito Tanaka,Akiko Inomata,Yoshiko Honda,Tohru Kodama
- 担当区分
- 概要
- 概要（英）
- We examined the effects of three benzofurans [1-(Benzofuran-5-yl)-N-methylpropan-2-amine (5-MAPB), 1-(Benzofuran-2-yl)-N-methylpropan-2-amine (2-MAPB), and 1-(Benzofuran-5-yl)-N-ethylpropan-2-amine (5-EAPB)] on the extracellular monoamine level in mouse corpus striatum by the microdialysis method and compared them with the effects of psychoactive 3,4-Methylenedioxymethamphetamine (MDMA). The effects of benzofurans on the extracellular monoamine level were qualitatively analogous to that of MDMA, with an increase in serotonin (5-HT) level exceeding dopamine (DA) level. The effects of 2-MAPB and 5-EAPB were almost the same as the effect of MDMA. However, 5-MAPB strongly increased extracellular monoamine level than MDMA. These differences in the potency appear to have a structure-activity relationship. The administration of 5-MAPB (1.6 x 10(-4) mol/kg B.W.) resulted in the death of two-thirds of the mice. The same dose of MDMA did not cause any deaths. The administration of 5-MAPB (1.6 x 10(-4) mol/kg B.W.) produced a 3.41 degrees C +/- 0.28 degrees C rise in rectal temperature after 1 hr, whereas the administration of MDMA (1.6 x 10(-4) mol/kg B.W.) produced an approximate 1.85 degrees C +/- 0.26 degrees C rise. These results suggest that benzofurans have 5-HT toxicity similar to MDMA, and 5-MAPB has a higher risk of lethal intoxication than MDMA. Furthermore, 5-APB, the metabolic product of 5-MAPB demethylation, may be involved in the acute 5-HT toxicity and may cause lethal intoxication in mice.
- 出版者・発行元
- 出版者・発行元（英）
- JAPANESE SOC TOXICOLOGICAL SCIENCES
- 誌名
- 誌名（英）
- JOURNAL OF TOXICOLOGICAL SCIENCES
- 巻
- 41
- 号
- 3
- 開始ページ
- 329
- 終了ページ
- 337
- 出版年月
- 2016年6月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0388-1350
- DOI URL
- https://doi.org/10.2131/jts.41.329
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )