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論文
- タイトル
- タイトル（英）
- Monoamine Release during Unihemispheric Sleep and Unihemispheric Waking in the Fur Seal
- 参照URL
- https://researchmap.jp/SleepLab/published_papers/28198931
- 著者
- 著者（英）
- Oleg I. Lyamin,Jennifer L. Lapierre,Peter O. Kosenko,Tohru Kodama,Adhil Bhagwandin,Svetlana M. Korneva,John H. Peever,Lev M. Mukhametov,Jerome M. Siegel
- 担当区分
- 概要
- 概要（英）
- Study Objectives: Our understanding of the role of neurotransmitters in the control of the electroencephalogram (EEG) has been entirely based on studies of animals with bilateral sleep. The study of animals with unihemispheric sleep presents the opportunity of separating the neurochemical substrates of waking and sleep EEG from the systemic, bilateral correlates of sleep and waking states. Methods: The release of histamine (HI), norepinephrine (NE), and serotonin (5HT) in cortical and subcortical areas (hypothalamus, thalamus and caudate nucleus) was measured in unrestrained northern fur seals (Callorhinus ursinus) using in vivo microdialysis, in combination with, polygraphic recording of EEG, electrooculogram, and neck electromyogram. Results: The pattern of cortical and subcortical HI, NE, and 5HT release in fur seals is similar during bilaterally symmetrical states: highest in active waking, reduced in quiet waking and bilateral slow wave sleep, and lowest in rapid eye movement (REM) sleep. Cortical and subcortical HI, NE, and 5HT release in seals is highly elevated during certain waking stimuli and behaviors, such as being sprayed with water and feeding. However, in contrast to acetylcholine (ACh), which we have previously studied, the release of HI, NE, and 5HT during unihemispheric sleep is not lateralized in the fur seal. Conclusions: Among the studied neurotransmitters most strongly implicated in waking control, only ACh release is asymmetric in unihemispheric sleep and waking, being greatly increased on the activated side of the brain.
- 出版者・発行元
- 出版者・発行元（英）
- AMER ACAD SLEEP MEDICINE
- 誌名
- 誌名（英）
- SLEEP
- 巻
- 39
- 号
- 3
- 開始ページ
- 625
- 終了ページ
- 636
- 出版年月
- 2016年3月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0161-8105
- DOI URL
- https://doi.org/10.5665/sleep.5540
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )