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論文
- タイトル
- タイトル（英）
- Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States
- 参照URL
- https://researchmap.jp/SleepLab/published_papers/28238079
- 著者
- 著者（英）
- Sachiko Chikahisa,Tohru Kodama,Atsushi Soya,Yohei Sagawa,Yuji Ishimaru,Hiroyoshi Sei,Seiji Nishino
- 担当区分
- 概要
- 概要（英）
- Mast cell activation and degranulation can result in the release of various chemical mediators, such as histamine and cytokines, which significantly affect sleep. Mast cells also exist in the central nervous system (CNS). Since up to 50% of histamine contents in the brain are from brain mast cells, mediators from brain mast cells may significantly influence sleep and other behaviors. In this study, we examined potential involvement of brain mast cells in sleep/wake regulations, focusing especially on the histaminergic system, using mast cell deficient (W/Wv) mice. No significant difference was found in the basal amount of sleep/wake between W/Wv mice and their wild-type littermates (WT), although W/Wv mice showed increased EEG delta power and attenuated rebound response after sleep deprivation. Intracerebroventricular injection of compound 48/80, a histamine releaser from mast cells, significantly increased histamine levels in the ventricular region and enhanced wakefulness in WT mice, while it had no effect in W/Wv mice. Injection of H1 antagonists (triprolidine and mepyramine) significantly increased the amounts of slow-wave sleep in WT mice, but not in W/Wv mice. Most strikingly, the food-seeking behavior observed in WT mice during food deprivation was completely abolished in W/Wv mice. W/Wv mice also exhibited higher anxiety and depression levels compared to WT mice. Our findings suggest that histamine released from brain mast cells is wake-promoting, and emphasizes the physiological and pharmacological importance of brain mast cells in the regulation of sleep and fundamental neurobehavior.
- 出版者・発行元
- 出版者・発行元（英）
- PUBLIC LIBRARY SCIENCE
- 誌名
- 誌名（英）
- PLOS ONE
- 巻
- 8
- 号
- 10
- 開始ページ
- 終了ページ
- 出版年月
- 2013年10月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 1932-6203
- DOI URL
- https://doi.org/10.1371/journal.pone.0078434
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )