※ をクリックすると外部の論文のサイトが開きます。
論文
- タイトル
- タイトル（英）
- CSF histamine levels in rats reflect the central histamine neurotransmission
- 参照URL
- https://researchmap.jp/SleepLab/published_papers/1028008
- 著者
- 著者（英）
- Atsushi Soya,You Hwi Song,Tohru Kodama,Yoshiko Honda,Nobuhiro Fujiki,Seiji Nishino
- 担当区分
- 概要
- 概要（英）
- Reduced cerebrospinal fluid (CSF) histamine levels were found in human hypersomnia. To evaluate the functional significance of changes in CSF histamine levels. we measured the levels in rats across 24 h, after the administration of wake-promoting compounds modafinil, amphetamine, and thioperamide, and after sleep deprivation and food deprivation. Thioperamide significantly increased CSF histamine levels with little effects on locomotor activation. Both modafinil and amphetamine markedly increased the locomotor activity, but had no effects on histamine. The levels are high during active period and are markedly elevated by sleep deprivation, but not by food deprivation. Our study suggests that CSF histamine levels in rats reflect the central histamine neurotransmission and vigilance state changes, providing deeper insight into the human data. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
- 出版者・発行元
- 出版者・発行元（英）
- ELSEVIER IRELAND LTD
- 誌名
- 誌名（英）
- NEUROSCIENCE LETTERS
- 巻
- 430
- 号
- 3
- 開始ページ
- 224
- 終了ページ
- 229
- 出版年月
- 2008年1月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0304-3940
- DOI URL
- https://doi.org/10.1016/j.neulet.2007.11.002
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )