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論文
- タイトル
- タイトル（英）
- Pael receptor is involved in dopamine metabolism in the nigrostriatal system
- 参照URL
- https://researchmap.jp/SleepLab/published_papers/1028010
- 著者
- 著者（英）
- Yuzuru Imai,Haruhisa Inoue,Ayane Kataoka,Wang Hua-Qin,Masao Masuda,Toshio Ikeda,Kayoko Tsukita,Mariiko Soda,Tohru Kodama,Tatsu Fuwa,Yoshiko Honda,Satoshi Kaneko,Sadayuki Matsumoto,Kazumasa Wakamatsu,Shosuke Ito,Masami Miura,Toshihiko Aosaki,Shigeyoshi Itohara,Ryosuke Takahashi
- 担当区分
- 概要
- 概要（英）
- Pael receptor (Pael-R) has been identified as one of the substrates of Parkin, a ubiquitin ligase responsible for autosomal recessive juvenile Parkinsonism (AR-JP). When Parkin is inactivated, unfolded Pael-R accumulates in the endoplasmic reticulum and results ill neuronal death by unfolded protein stress, suggesting that Pael-R has an important role in the pathogenesis of AR-JP. Here we report the analyses on Pael-R-deficient (KO) and Pael-R-transgenic (Tg) mice. The striatal dopamine (DA) level of Pael-R KO mice was only 60% of that in normal mice, while in Pael-R Tg mice, striatal 3,4-dihydroxyphenylacetic acid (DOPAC) as well as vesicular DA content increased. Moreover, the nigrostriatal dopaminergic neurons of Pael-R Tg mice are more vulnerable to Parkinson's disease-related neurotoxins while those of Pael-R KO mice are less. These results strongly suggest that the Pael-R signal regulates the amount of DA in the dopaminergic neurons and that excessive Pael-R expression renders dopaminergic neurons susceptible to chronic DA toxicity. (C) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
- 出版者・発行元
- 出版者・発行元（英）
- ELSEVIER IRELAND LTD
- 誌名
- 誌名（英）
- NEUROSCIENCE RESEARCH
- 巻
- 59
- 号
- 4
- 開始ページ
- 413
- 終了ページ
- 425
- 出版年月
- 2007年12月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0168-0102
- DOI URL
- https://doi.org/10.1016/j.neures.2007.08.005
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )