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論文
- タイトル
- タイトル（英）
- Single-nucleotide polymorphisms of the <i>SLC17A9</i> and <i>P2RY12</i> genes are significantly associated with phantom tooth pain
- 参照URL
- https://researchmap.jp/kazutakaikeda/published_papers/36522430
- 著者
- 著者（英）
- Moe Soeda,Seii Ohka,Daisuke Nishizawa,Junko Hasegawa,Kyoko Nakayama,Yuko Ebata,Ken-ichi Fukuda,Kazutaka Ikeda
- 担当区分
- 概要
- 概要（英）
- Phantom tooth pain (PTP) is a rare and specific neuropathic pain that occurs after pulpectomy and tooth extraction, but its cause is not understood. We hypothesized that there is a genetic contribution to PTP. We focused on solute carrier family 17 member 9 (SLC17A9)/vesicular nucleotide transporter (VNUT) and purinergic receptor P2Y12 (P2RY12), both of which have been associated with neuropathic pain and pain transduction signaling in the trigeminal ganglion in rodents. We sought to corroborate these associations in humans. We investigated gene polymorphisms that contribute to PTP. We statistically examined the association between genetic polymorphisms and PTP vulnerability in 150 patients with orofacial pain, including PTP, and 500 healthy subjects. We found that the rs735055 polymorphism of the <i>SLC17A9</i> gene and rs3732759 polymorphism of the <i>P2RY12</i> gene were associated with the development of PTP. Carriers of the minor allele of rs735055 and individuals who were homozygous for the major allele of rs3732759 had a higher rate of PTP. Carriers of the minor allele of rs735055 reportedly had high <i>SLC17A9</i> mRNA expression in the spinal cord, which may increase the storage and release of adenosine triphosphate. Individuals who were homozygous for the major allele of rs3732759 may have higher P2RY12 expression that is more active in microglia. Therefore, these carriers may be more susceptible to PTP. These results suggest that specific genetic polymorphisms of the <i>SLC17A9</i> and <i>P2RY12</i> genes are involved in PTP. This is the first report on genes that are associated with PTP in humans.
- 出版者・発行元
- 出版者・発行元（英）
- SAGE Publications
- 誌名
- 誌名（英）
- Molecular Pain
- 巻
- 号
- 開始ページ
- 174480692210895
- 終了ページ
- 174480692210895
- 出版年月
- 2022年3月10日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 1744-8069
- DOI URL
- https://doi.org/10.1177/17448069221089592
- 共同研究・競争的資金等の研究課題