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論文
- タイトル
- タイトル（英）
- Dopamine activity in projection neurons regulates short-lasting olfactory approach memory in Drosophila.
- 参照URL
- https://researchmap.jp/minorusaitoe/published_papers/38616226
- 著者
- 著者（英）
- Shintaro Naganos,Kohei Ueno,Junjiro Horiuchi,Minoru Saitoe
- 担当区分
- 概要
- 概要（英）
- Survival in many animals requires the ability to associate certain cues with danger and others with safety. In a Drosophila melanogaster aversive olfactory conditioning paradigm, flies are exposed to two odors, one presented coincidentally with electrical shocks, and a second presented 45 seconds after shock cessation. When flies are later given a choice between these two odors, they avoid the shock-paired odor, and prefer the unpaired odor. While many studies have examined how flies learn to avoid the shock-paired odor through formation of odor-fear associations, here we demonstrate that conditioning also causes flies to actively approach the second odor. In contrast to fear memories which are longer lasting and requires activity of D1-like dopamine receptors only in the mushroom bodies, approach memory is short-lasting, and requires activity of D1-like dopamine receptors in projection neurons originating from the antennal lobes, primary olfactory centers. Further, while recall of fear memories requires activity of the mushroom bodies, recall of approach memories does not. Our data suggest that olfactory approach memory is formed using different mechanisms in different brain locations compared to aversive and appetitive olfactory memories.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- The European journal of neuroscience
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2022年7月11日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1111/ejn.15766
- 共同研究・競争的資金等の研究課題