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論文
- タイトル
- タイトル(英)
- A Drosophila model of diabetic neuropathy reveals a crucial role of proteasome activity in the glia
- 参照URL
- https://researchmap.jp/351K/published_papers/40195204
- 著者
- 著者(英)
- Mari Suzuki,Hiroshi Kuromi,Mayumi Shindo,Nozomi Sakata,Naoko Niimi,Koji Fukui,Minoru Saitoe,Kazunori Sango
- 担当区分
- 概要
- 概要(英)
- SUMMARY Diabetic peripheral neuropathy (DPN) is the most common chronic, progressive complication of diabetes mellitus. The main symptom is sensory loss; the molecular mechanisms are not fully understood. We found that Drosophila fed a high-sugar diet, which induces diabetes-like phenotypes, exhibit impairment of noxious heat avoidance. The impairment of heat avoidance was associated with shrinkage of the leg neurons expressing the Drosophila transient receptor potential channel Painless. Using a candidate genetic screening approach, we identified proteasome modulator 9 as one of the modulators of impairment of heat avoidance. We further showed that proteasome inhibition in the glia reversed the impairment of noxious heat avoidance, and heat-shock proteins and exosome secretion in the glia mediated the effect of proteasome inhibition. Our results establish Drosophila as a useful system for exploring molecular mechanisms of diet-induced peripheral neuropathy and propose that the glial proteasome is one of the candidate therapeutic targets for DPN.
- 出版者・発行元
- 出版者・発行元(英)
- Cold Spring Harbor Laboratory
- 誌名
- 誌名(英)
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2022年9月23日
- 査読の有無
- 招待の有無
- 掲載種別
- ISSN
- DOI URL
- https://doi.org/10.1101/2022.09.22.509008
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