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論文
- タイトル
- タイトル（英）
- Non-invasive brain-spine interface: Continuous control of trans-spinal magnetic stimulation using EEG
- 参照URL
- https://researchmap.jp/kore2460/published_papers/40387924
- 著者
- 著者（英）
- Ainhoa Insausti-Delgado,Eduardo López-Larraz,Yukio Nishimura,Ulf Ziemann,Ander Ramos-Murguialday
- 担当区分
- 概要
- 概要（英）
- Brain-controlled neuromodulation has emerged as a promising tool to promote functional recovery in patients with motor disorders. Brain-machine interfaces exploit this neuromodulatory strategy and could be used for restoring voluntary control of lower limbs. In this work, we propose a non-invasive brain-spine interface (BSI) that processes electroencephalographic (EEG) activity to volitionally control trans-spinal magnetic stimulation (ts-MS), as an approach for lower-limb neurorehabilitation. This novel platform allows to contingently connect motor cortical activation during leg motor imagery with the activation of leg muscles via ts-MS. We tested this closed-loop system in 10 healthy participants using different stimulation conditions. This BSI efficiently removed stimulation artifacts from EEG regardless of ts-MS intensity used, allowing continuous monitoring of cortical activity and real-time closed-loop control of ts-MS. Our BSI induced afferent and efferent evoked responses, being this activation ts-MS intensity-dependent. We demonstrated the feasibility, safety and usability of this non-invasive BSI. The presented system represents a novel non-invasive means of brain-controlled neuromodulation and opens the door towards its integration as a therapeutic tool for lower-limb rehabilitation.
- 出版者・発行元
- 出版者・発行元（英）
- Frontiers Media SA
- 誌名
- 誌名（英）
- Frontiers in Bioengineering and Biotechnology
- 巻
- 10
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2022年10月31日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3389/fbioe.2022.975037
- 共同研究・競争的資金等の研究課題
研究者
西村 幸男
( )