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論文
タイトル
タイトル(英)
Towards an understanding of the pathological basis of senile depression and incident dementia: Implications for treatment.
参照URL
https://researchmap.jp/Ito_K/published_papers/40428744
著者
著者(英)
Ito Kawakami,Jun-Ichi Iga,Sho Takahashi,Yi-Ting Lin,Hiroshige Fujishiro
担当区分
概要
概要(英)
Senile depression (SD) is a heterogeneous syndrome. Several clinical profiles are more likely to appear in SD than in early-life depression, but it remains unclear whether the pathophysiology is different. The prevalence of dementia increases with aging, and the underlying pathophysiological processes in the preclinical phase begin even before cognitive deficits or neurological signs appear. SD may be either a risk factor for developing dementia or a prodromal stage of dementia. The inconsistent findings regarding the association between SD and incident dementia may be attributable to the neuropathological heterogeneity underlying SD. Most studies have focused on patients with the clinical diagnosis of Alzheimer disease (AD) as an outcome, but several clinicopathological studies suggest that primary age-related tauopathy and argyrophilic grain disease may account for a proportion of cases clinically misdiagnosed as AD in the elderly population. Furthermore, most AD cases have additional neuropathologic changes such as cerebrovascular disease and Lewy body disease. Here, we review the neuropathological findings linking SD to incident dementia, focusing on common age-related neuropathologies. In particular, the roles of disturbance of neural circuity, imbalance of monoaminergic systems, dysregulation of the hypothalamic-pituitary-adrenal axis, and elevated neuroinflammatory status are discussed. Finally, we review the current treatment of SD in the context of age-related neuropathological changes.
出版者・発行元
出版者・発行元(英)
誌名
誌名(英)
Psychiatry and clinical neurosciences
開始ページ
終了ページ
出版年月
2022年10月2日
査読の有無
招待の有無
掲載種別
研究論文(学術雑誌)
ISSN
DOI URL
https://doi.org/10.1111/pcn.13485
共同研究・競争的資金等の研究課題
研究者
河上 緒 (カワカミ イト)